background: crimean-congo hemorrhagic fever (cchf) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. hypoxia inducible factor-1α (hif-1α) and vascular endothelial growth factor-a (vegf-a) play an important role both in the inflamma­tory process and plasma leakage. the aim of this study was to de...

Hypoxia-inducible factor-1 (HIF-1), which is present at higher levels in human tumors, plays important roles in tumor promotion. It is composed of HIF-1 and HIF-1 subunits and its activity depends on the amount of HIF-1 , which is tightly controlled by cellular oxygen tension. In addition to hypoxia, various nonhypoxic stimuli can stabilize HIF-1 in tumor cells, implying that both hypoxic and n...

Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen and vital to many aspects of cancer biology. In a search for HIF-1 inhibitors, we identified celastrol as an inhibitor of HIF-1 activation from Tripterygium wilfordii. In the present study, we demonstrated the effect of celastrol on HIF-1 activation. Celastrol showed a potent inhibitory activity again...

Dokudaki gerekli oksijen seviyesinin normal değerin altına düşmesi hipoksi olarak tanımlanır. Hipoksi katı tümör-lerde sık karşılaşılan bir durumdur. Tümör hücreleri yeterli alamadığında hücre ölümüne gitmeden önce genetik farklılıklar oluşturarak hipoksik duruma adapte olmaktadır. Bazı tümörlerde radyo veya kemoterapötik tedavi direncinin gelişiminde hipoksinin rol oynadığı gösterilmiştir. Bir...

Although our understanding of the molecular regulation of adult neovascularization has advanced tremendously, vascular-targeted therapies for tissue ischemia remain suboptimal. The master regulatory transcription factors of the hypoxia-inducible factor (HIF) family are attractive therapeutic targets because they coordinately up-regulate multiple genes controlling neovascularization. Here, we us...

Monocytes/macrophages of the myeloid lineage are the main cellular effectors of innate immunity. Hypoxia-inducible factor 1 (HIF-1) is essential for myeloid cell activation in response to inflammatory stimuli. However, it has not been established whether HIF-1 activity is induced during differentiation from monocyte to macrophage. We demonstrate that macrophage differentiation of THP-1 cells or...

Hypoxia-inducible factors (HIF-1 and HIF-2) are essential mediators for the adaptive transcriptional response of cells and tissues to low-oxygen conditions. Under hypoxia or when cells are treated with various nonhypoxic stimuli, the active HIF-α subunits are mainly regulated through increased protein stabilization. For HIF-1α, it is clear that further transcriptional, translational, and posttr...