نتایج جستجو برای: لایه کاملا سازگار pml
تعداد نتایج: 40587 فیلتر نتایج به سال:
BACKGROUND Progressive multifocal leukoencephalopathy (PML) in natalizumab-treated MS patients is linked to JC virus (JCV) infection. JCV sequence variation and rearrangements influence viral pathogenicity and tropism. To better understand PML development, we analyzed viral DNA sequences in blood, CSF and/or urine of natalizumab-treated PML patients. METHODS Using biofluid samples from 17 nat...
Acute promyelocytic leukemia (APL) is driven by a chromosomal translocation whose product, the PML/retinoic acid (RA) receptor α (RARA) fusion protein, affects both nuclear receptor signaling and PML body assembly. Dissection of APL pathogenesis has led to the rediscovery of PML bodies and revealed their role in cell senescence, disease pathogenesis, and responsiveness to treatment. APL is rema...
Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PML, hDaxx, Sp100, or ATRX protein, that are able to act as cellular restriction...
یک سیستم همیلتونی روی یک خمینه ی پواسون m در صورتی انتگرال پذیر نامیده می شود که شامل تعداد کافی انتگرال اول f_1...f_s باشد که این انتگرال ها دو به دو جا به جا می شوند و تقریبا همه جا روی m مستقل تابعی باشند. در این پایان نامه ساختار مجموعه ی تکین k که در آن دیفرانسیل های f_1...f_s وابسته ی خطی می شوند را مطالعه می کنیم و نشان می دهیم در سیستم های دو هامیلتونی،این ساخنار با با ویژگی های دسته بر...
یکی از مهمترین بیوسرامیک های مورد استفاده در پزشکی که تحقیقات زیادی را به خود اختصاص داده است هیدروکسی آپاتیت (ha) می باشد. هیدروکسی آپاتیت به دلیل نزدیک بودن ترکیب شیمیایی به بخش معدنی استخوان و در نتیجه زیست سازگاری عالی برای سال های زیادی به عنوان ماده کلینیکی و جایگزین استخوان مورد استفاده قرار گرفته است. مشکل اصلی هیدروکسی آپاتیت خالص مقاومت مکانیکی ضعیف آن است. در این کار پژوهشی با توجه...
Promyelocytic leukemia protein (PML), the main constituent of PML nuclear bodies, regulates various physiological processes in different cell types. However, little is known about its functions in embryonic stem cells (ESC). Here, we report that PML contributes to ESC self-renewal maintenance by controlling cell-cycle progression and sustaining the expression of crucial pluripotency factors. Tr...
The AML1-CBFbeta transcription factor complex is the most frequent target of specific chromosome translocations in acute myeloid leukemia (AML). The promyelocytic leukemia (PML) gene is also frequently involved in AML-associated translocation. Here we report that a specific isoform PML I forms a complex with AML1. PML I was able to recruit AML1 and coactivator p300 in PML nuclear bodies and enh...
The promyelocytic leukemia (PML) gene is a tumor suppressor gene. It was first identified in acute promyelocytic leukemia, in which it is fused to retinoic acid receptor α by the (15;17) chromosomal translocation. The function of the PML protein is frequently lost or aberrant in human solid tumors. In human ovarian carcinoma tissue, PML detected by immunohistochemistry was highly expressed. A P...
Mitotic accumulations of PML protein contribute to the re-establishment of PML nuclear bodies in G1.
Although the mechanism of chromosomal segregation is well known, it is unclear how other nuclear compartments such as promyelocytic leukemia (PML) nuclear bodies partition during mitosis and re-form in G1. We demonstrate that PML nuclear bodies partition via mitotic accumulations of PML protein (MAPPs), which are distinct from PML nuclear bodies in their dynamics, biochemistry and structure. Du...
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