The abundance of miR-132 ranges from constitutively high in the brain where it is necessary for neuronal development and function, to inducible expression in haematopoietic and endothelial cells where it controls angiogenesis and immune activation. We show that expression of AGO2, a protein central to miRNA-mediated gene silencing and miRNA biogenesis, is negatively regulated by miR-132. Using ...

BACKGROUND Impaired visual memory seems to be a core feature of depression, while increased microRNA-132 (miR-132) levels have been widely reported in depression patients. The authors aimed to explore the relationship between miR-132 changes and visual memory deficits in unmedicated patients with major depressive disorder (MDD). PATIENTS AND METHODS A total of 62 medication-free MDD patients ...

OBJECTIVES Previous studies have demonstrated that microRNA-132 plays a vital part in and is actively associated with several cancers, with its tumor-suppressive role in hepatocellular carcinoma confirmed. The current study employed multiple bioinformatics techniques to establish gene signatures for hepatocellular carcinoma, microRNA-132 predicted target genes and the corresponding overlaps. ...

The microRNAs (miRNAs) miR-132 and miR-212 have been found to regulate synaptic plasticity and cholinergic signaling and recent work has demonstrated roles outside of the CNS, including in smooth muscle. Here, we examined if miR-132 and miR-212 are induced in the urinary bladder following outlet obstruction and whether this correlates with effects on gene expression and cell growth. Three to se...

The popularity of a pattern p in a set of permutations is the sum of the number of copies of p in each permutation of the set. We study pattern popularity in the set of 132-avoiding permutations. Two patterns are equipopular if, for all n, they have the same popularity in the set of length-n 132-avoiding permutations. There is a well-known bijection between 132-avoiding permutations and binary ...

The diagram of a 132-avoiding permutation can easily be characterized: it is simply the diagram of a partition. Based on this fact, we present a new bijection between 132-avoiding and 321-avoiding permutations. We will show that this bijection translates the correspondences between these permutations and Dyck paths given by Krattenthaler and by Billey-Jockusch-Stanley, respectively, to each oth...

s of papers 31 Saturday, PM, ENVIRONMENT AND MANAGEMENT A 132 Temperature heterogeneity and moisture accumulation in trailers transporting broilers under Canadian winter conditions. T.D. Knezacek*1, G.F. Audren1, M.A. Mitchell2, P.J. Kettlewell3, R.R. Hunter2, H.L. Classen1, S. Stephens1, A.A. Olkowski1, E.M. Barber1, and T.G. Crowe1, 1University of Saskatchewan, Saskatoon, SK, Canada, 2Roslin ...

The popularity of a pattern p is the total number of copies of p within all permutations of a set. We address popularity in the set of 132-avoidng permutations. Bóna showed that in this set, all other non-monotone length-3 patterns are equipopular, and proved equipopularity relations between some length-k patterns of a specific form. We prove equipopularity relations between general length-k pa...

Agouti signaling protein (ASIP), the human (h) homolog of agouti, is an endogenous melanocortin peptide antagonist. To date, characterization of this protein has been performed with recombinant protein only and without the availability of an ASIP/agouti radioligand. In this report we describe the functional characteristics of a chemically synthesized truncated ASIP variant, ASIP-[90-132 (L89Y)]...