This paper provides a lifecycle cost-benefit analysis of the use of Prognostics and Health Management (PHM) systems in future or present commercial aircraft. The approach considers individual aircraft component’s failure behavior, prognostic performance levels including prognostic errors, and condition-based maintenance (CBM) concepts. The proposed methodology is based on a discrete-event simul...

Schistosoma mansoni venom allergen-like protein 4 (SmVAL4) is a novel lipid-binding SCP/TAPS protein that lacks the prototypical CAP motifs. Corrigendum Figure 6(a) of the article by Kelleher et al. In the article by Kelleher et al. (2014), Fig. 6(a) was incorrect and the locations of the CBM and Crisp1 were missing. The correct Fig. 6(a) is published here and the CBM and Crisp1 are now shown w...

This paper presents a method of automated synthesis of reversible cascades in a special cellular automaton called CAM-Brain Machine (CBM). Reversible circuits are investigated because they are expected to dissipate much less energy than their irreversible counterparts. It is believed that one day they will be implemented as nano-scale 3-dimensional chips. A circuit is reversible if the number o...

Antigen receptor-mediated nuclear factor κB (NF-κB) activation relies on the formation of a large multi-protein complex that contains CARMA1, BCL10, and MALT1 (CBM complex). This signalosome is pirated in the activated B-cell-like subgroup of diffuse large B-cell lymphoma (ABC DLBCL) to drive aberrant NF-κB activation, thereby promoting cell survival and propagation. Using an unbiased proteomic...

Within the last 3 y, a new type of technology has emerged for PET imaging that uses a continuous-bed-motion (CBM) acquisition. For technologists, this type of acquisition requires some modifications of the standard approach to PET protocols and imaging workflows. There are several key aspects of CBM that technologists need to learn and understand when transitioning from traditional step-and-sho...

This paper presents an introductory review of CBM practice applied in manufacturing industry, focusing the technical constituents within condition monitoring. The empirical base for the study is a case study of two major manufacturing sites in Sweden, complemented with a brief benchmark of data from two reference manufacturing sites from France and Brazil. The data from the main studies were co...

Department of Industrial Engineering, Tel Aviv University, Ramat Aviv, Israel ABSTRACT Condition-based maintenance (CBM) is increasingly applied to operational systems to reduce lifecycle costs. Predicting the performance of various CBM policies is a challenging task addressed in this work. We suggest a CBM framework that is based on system simulations and a targeted Bayesian network model. Sim...

Glycoside hydrolases often possess carbohydrate-binding modules (CBMs) in addition to their catalytic domains, which help target the enzymes to appropriate substrates and thereby increase their catalytic efficiency. Sialidases hydrolyse the release of sialic acid from a variety of glycoconjugates and play significant roles in the pathogenesis of a number of important diseases. The sialidase fro...

The physics goals of the CBM experiment call for unprecedented flavour tagging performances out of reach of established silicon pixel detector technologies. Monolithic Active Pixel Sensors (MAPS), developed in collaboration by IReS and LEPSI in Strasbourg since 1999, are promising candidates for the CBM vertex detector. A MAPS-prototype made of 1 million pixels covering a surface of 3.5cm2, thi...

The paper will provide a lifecycle cost-benefit analysis of the use of Prognostics and Health Management (PHM) systems and a conditioned-based maintenance (CBM) concept in future aircraft. The proposed methodology is based on a discrete-event simulation for aircraft operation and maintenance and uses an optimization algorithm for the planning and scheduling of CBM tasks. In the study, a 150seat...