Interkinetic nuclear migration (INM), the movement of neuroepithelial and radial glial cell nuclei along the apical-basal axis in concert with the cell cycle, underlies the pseudostratification of the ventricular zone (VZ). Recent studies provide insight into the molecular mechanisms of INM and its effects on neural progenitor cell fate determination. Moreover, INM not only has a key role in in...

Dmytro Grytskyy, Markus Diesmann, 3 and Moritz Helias 3 Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany Department of Physics, Faculty 1, RWTH...

The nuclei of dividing neural progenitors undergo a cell-cycle-dependent change in position along the apico-basal axis known as interkinetic nuclear migration (INM). The functional relationship between INM and the mode of division of neural progenitors remains elusive, in part because its regulation at the molecular level is poorly understood. In this issue of Neuron, Xie et al. identify two ce...

The mammalian cerebral cortex develops from proliferative apical progenitor cells (APs) that exhibit cell cycle-dependent nuclear movement (interkinetic nuclear migration; INM), which may be important for efficient and continuous production of neurons. The Pax6 transcription factor plays a major role in INM by regulating various downstream molecules. We have previously observed abnormal INM and...

The increasing number of pertussis cases reported on the last twenty years and the existence of new acellular vaccines reinforce the need of research for experimental models to assure the quality of available pertussis vaccines. In this study, allotments of whole-cell and acellular pertussis vaccines were tested through the Intranasal Challenge Model (INM) using conventional NIH mice. The resul...

Getting to the inner circle ontiguity between the ER and the nuclear envelope means nuclear membrane proteins have a direct shot to their target. In fact, inner nuclear membrane (INM) proteins were thought to need only to diffuse to the nucleus, pass through the nuclear pore, and then be retained by nuclear-localized binding partners. But new results suggest a more active process. Suraj Saksena...

هدف: با توجه به نگرانی‌های اجتماعی موجود در سال‌های اخیر دلیل بحران‌های اقتصادی، اجتماعی، مالی و زیست‌محیطی ناشی از تحریم‌ها، خط‌مشی دولت‌ها برای افزایش تاب‌آوری سمت اقتصاد مقاومتی سوق پیدا کرده است. هدف این پژوهش طراحی تبیین مدل سیاست‌گذاری دولت الکترونیک رویکرد وزارت علوم است.طراحی/ روش‌شناسی/ رویکرد: تحقیق حاضر لحاظ کاربردی توسعه‌ای بوده تکنیک تحلیل تم حاصل مصاحبه مدیران عالی اساتید دانشگاه ...

TorsinA (also known as torsin-1A) is a membrane-embedded AAA+ ATPase that has an important role in the nuclear envelope lumen. However, most torsinA is localized in the peripheral endoplasmic reticulum (ER) lumen where it has a slow mobility that is incompatible with free equilibration between ER subdomains. We now find that nuclear-envelope-localized torsinA is present on the inner nuclear mem...

Spodoptera frugiperda (Sf9) importin-alpha-16 is a translocon-associated protein that participates in the early sorting pathway of baculovirus integral membrane proteins destined for the inner nuclear membrane (INM). To discern whether sorting intermediate protein complexes like those observed in insect cells are also formed with mammalian INM proteins, cross-linked complexes of importin-alpha-...

Sensory afferent signals from neck muscles have been postulated to influence central cardiorespiratory control as components of postural reflexes, but neuronal pathways for this action have not been identified. The intermedius nucleus of the medulla (InM) is a target of neck muscle spindle afferents and is ideally located to influence such reflexes but is poorly investigated. To aid identificat...