BACKGROUND Loss of muscle mass due to prolonged bed rest decreases functional capacity and increases hospital morbidity and mortality in older adults. OBJECTIVE To determine if HMB, a leucine metabolite, is capable of attenuating muscle decline in healthy older adults during complete bed rest. DESIGN A randomized, controlled, double-blinded, parallel-group design study was carried out in 24...

The purpose of the present study was to determine the effects of short-term supplementation with the free acid form of b-hydroxyb-methylbutyrate (HMB-FA) on indices of muscle damage, protein breakdown, recovery and hormone status following a high-volume resistance training session in trained athletes. A total of twenty resistance-trained males were recruited to participate in a high-volume resi...

Heavy menstrual bleeding (HMB) is a common problem in adolescent girls where it comprises a significant public health problem [1]. HMB affects almost one-third of adolescent girls at the time of the menarche. Reports from multiple studies indicate that between 5 and 10 percent of young girls in this age group will seek medical treatment and of those, approximately one-half will experience surgi...

BACKGROUND Heavy menstrual bleeding (HMB) is a common, chronic problem affecting women and health services. However, long-term evidence on treatment in primary care is lacking. AIM To assess the effectiveness of commencing the levonorgestrel-releasing intrauterine system (LNG-IUS) or usual medical treatments for women presenting with HMB in general practice. DESIGN AND SETTING A pragmatic, ...

Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers. Among them, stem-like cells (hMB-SLCs) represent a fraction of the tumor cell population with the potential of self-renewal and proliferation and have been associated with tumor poor prognosis. In this context, microRNAs have been descri...

[1] We present a long-term study, from January 1996 to August 2012, of the latitude of the Heppner-Maynard Boundary (HMB) measured at midnight using the northern hemisphere Super Dual Auroral Radar Network (SuperDARN). The HMB represents the equatorward extent of ionospheric convection and is used in this study as a measure of the global magnetospheric dynamics. We find that the yearly distribu...

Malignant melanoma (MM) is a type of malignant tumor, which originates from neural crest melanocytes. MM progresses rapidly and results in a high mortality rate. The present study aims to investigate the expression of microphthalmia transcription factor (MITF), the S100 protein, and HMB-45 in MM and pigmented nevi. A total of 32 MM samples (including three skin metastasis, three lymph node meta...

OBJECTIVE To evaluate with immunohistochemical methods 5 atypical melanocytic conjunctival lesions. METHODS This was a retrospective clinicoimmunopathologic study. Routine histochemical staining was performed with multiparametric immunohistochemical analysis with monoclonal antibodies immunoreacted on paraffin sections to identify the following cell antigens: S-100, MART-1, HMB-45, CD45, CD68...

PURPOSE To evaluate the patient satisfaction and health related quality of life (HRQoL) for levonorgestrel-releasing intrauterine system (LNG-IUS) versus conventional medical treatments ([CMTs] combined oral contraceptives, oral progestins, and antifibrinolytics, alone or in combination) in Asian women with heavy menstrual bleeding (HMB). PATIENTS AND METHODS A total of 647 patients diagnosed...

This paper addresses the problem of multi-target tracking with superpositional sensors, while covariance matrices measurement noise are not known. The proposed method is based on hybrid multi-Bernoulli cardinalized probability hypothesis density (HMB-CPHD) filter, which has been developed for sensors-based known noises. Specifically, we firstly propose Gaussian mixture (GM) implementation HMB-C...