Background—Clinical predictors for fatal pulmonary embolism (PE) in patients with venous thromboembolism have never been studied. Methods and Results—Using data from the international prospective Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) registry about patients with objectively confirmed symptomatic acute venous thromboembolism, we determined independent predictive f...

There are ongoing debates about the definition, classification and prevalence of premature ejaculation (PE). The first evidence-based definition of PE was limited to heterosexual men with lifelong PE who engage in vaginal intercourse. Unfortunately, many patients with the complaint of PE do not meet these criteria. However, these men can be diagnosed as one of the PE subtypes, namely acquired P...

Engaging in emotional suppression typically has negative consequences. However, relatively little is known about response-focused emotion regulation processes in dyadic interactions. We hypothesized that interacting with suppressive partners would be more threatening than interacting with expressive partners. To test predictions, two participants independently watched a negatively-valenced vide...

OBJECTIVE To compare the performance of screening for pre-eclampsia (PE) based on risk factors from medical history, as recommended by NICE and ACOG, with the method proposed by The Fetal Medicine Foundation (FMF), which uses Bayes' theorem to combine the a-priori risk from maternal factors, derived by a multivariable logistic model, with the results of various combinations of biophysical and b...

The retinal pigment epithelium (RPE) lying along the vertical meridian of the eyes of wild-type (+/+) and pearl mutant (pe/pe) mice was examined with electron microscopy and microspectrophotometry in order to compare differences in melanosome location, size, numerical density, volume density, and melanin concentration. In +/+ mice the fraction of melanosomes that lie in the apical processes was...

BACKGROUND The Pulmonary Embolism Rule-out Criteria (PERC) rule is a clinical diagnostic rule designed to exclude pulmonary embolism (PE) without further testing. We sought to externally validate the diagnostic performance of the PERC rule alone and combined with clinical probability assessment based on the revised Geneva score. METHODS The PERC rule was applied retrospectively to consecutive...

OBJECTIVE To examine the diagnostic accuracy of a previously developed model for prediction of pre-eclampsia (PE) by a combination of maternal factors and biomarkers at 11-13 weeks' gestation. METHODS This was a prospective first-trimester multicenter study of screening for PE in 8775 singleton pregnancies. A previously published algorithm was used for the calculation of patient-specific risk...