Human skin contains various populations of memory T cells in permanent residence and in transit. Arguably, the best characterized of the skin subsets are the CD8(+) permanently resident memory T cells (TRM) expressing the integrin subunit, CD103. In order to investigate the remaining skin T cells, we isolated skin-tropic (CLA(+)) helper T cells, regulatory T cells, and CD8(+) CD103(-) T cells f...

Essential tremor (ET) is a common movement disorder with a poorly understood etiology. The TRM/Kyo mutant rat, showing spontaneous tremor, is an animal model of ET. Recently, we demonstrated that tremors in these rats emerge when two mutant loci, a missense mutation in the hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 (Hcn1) and the tremor (tm) deletion, are present si...

The yearly, cyclic impact of viruses like influenza on human health and the economy is due to the high rates of mutation of traditional antibody targets, which negate any preexisting humoral immunity. However, the seasonality of influenza infections can equally be attributed to an absent or defective memory CD8 T cell response since the epitopes recognized by these cells are derived from essent...

Introduction: Allogeneic hematopoietic stem cell transplantation (ASCT) representes a potentially curative approach for patients with relapsed or refractory acute myeloid leukemia (AML). We report the outcome of relapsed/refractory AML patients treated with ASCT. Method: A retrospective cohort from 1994 to 2013 that included 61 patients with diagnosis of relapsed/refractory AML. Outcomes of i...

The optimal primary endpoint for acute graft-versus-host disease (GVHD) therapeutic trials has not been established. In a retrospective analysis, we examined the response of 864 patients who received prednisone 60 mg/m(2)/d for 14 days, followed by an 8-week taper, as initial therapy for acute GVHD from 1990-2007 at the University of Minnesota. Patients received grafts of human leukocyte antige...

We establish the unexpected equality of the optimal volume density of total flux of a linear vector field x 7−→ Mx and the least volume fraction that can be swept out by submacroscopic switches, separations, and interpenetrations associated with the purely submacroscopic structured deformation (i, I +M). This equality is established first by identifying a dense set S of N×N matrices M for which...

Sixty patients undergoing allogeneic bone marrow transplant for acute myeloid leukemia (AML) in first remission (CR1; n = 49) or more advanced phase (n = 11) were entered in a prospective trial of graft-versus-host disease (GvHD) prophylaxis: low-dose cyclosporin A (IdCSA; 1 mg/kg/d from day -1 to +20 day; n = 28) or IdCSA plus low-dose methotrexate (IdMTX; 10 mg/m2 for day +1, 8 mg/m2 for days...

Tidal river management (TRM) is a building-with-nature practise which was locally developed to tackle the problems of polderization in south-western delta Bangladesh. This subsequently adapted by public agencies. However, all TRM sites are associated with violent conflict. While law-enforcement agencies have often struggled bring such conflict under control, there variation extent has been reso...

We recently reported the outcomes of 421 consecutive patients with immunoglobulin light chain (AL) amyloidosis treated with highdose melphalan and autologous stem cell transplantation (HDM/ SCT)1 from July 1994 through December 2008. Median survival was 6.3 years and the complete response rate for evaluable patients was 43%. Treatment-related mortality (TRM) was 11.4%. In other studies of HDM/S...