نتایج جستجو برای: ژن ezh2

تعداد نتایج: 18491  

2014
William W Hwang Ryan D Salinas Jason J Siu Kevin W Kelley Ryan N Delgado Mercedes F Paredes Arturo Alvarez-Buylla Michael C Oldham Daniel A Lim

The epigenetic mechanisms that enable specialized astrocytes to retain neurogenic competence throughout adult life are still poorly understood. Here we show that astrocytes that serve as neural stem cells (NSCs) in the adult mouse subventricular zone (SVZ) express the histone methyltransferase EZH2. This Polycomb repressive factor is required for neurogenesis independent of its role in SVZ NSC ...

Journal: :Immunity 2015
Michel DuPage Gaurav Chopra Jason Quiros Wendy L Rosenthal Malika M Morar Dan Holohan Ruan Zhang Laurence Turka Alexander Marson Jeffrey A Bluestone

Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling is essential for establishing diverse cellular identities, but how the epigenetic program in Treg cells is maintained throughout the dynamic activation process remains unclear. Here we have shown that CD28 co-stimulation, an extracellular cue intrinsically required for Treg cell maintenance, induced the ch...

2017
Ke-Sin Yan Chia-Yuan Lin Tan-Wei Liao Cheng-Ming Peng Shou-Chun Lee Yi-Jui Liu Wing P. Chan Ruey-Hwang Chou

Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 functions as a double-facet molecule in regulation of gene expression via repression or activation mechanisms, depending on the different cellular contexts. EZH2 interacts with both histone and non-histone pr...

Journal: :FEBS letters 2012
Christina R Majer Lei Jin Margaret Porter Scott Sarah K Knutson Kevin W Kuntz Heike Keilhack Jesse J Smith Mikel P Moyer Victoria M Richon Robert A Copeland Tim J Wigle

Heterozygous point mutations at Y641 and A677 in the EZH2 SET domain are prevalent in about 10-24% of Non-Hodgkin lymphomas (NHL). Previous studies indicate that these are gain-of-function mutations leading to the hypertrimethylation of H3K27. These EZH2 mutations may drive the proliferation of lymphoma and make EZH2 a molecular target for patients harboring these mutations. Here, another EZH2 ...

Journal: :Cancer research 2012
Gang Ren Stavroula Baritaki Himangi Marathe Jingwei Feng Sungdae Park Sandy Beach Peter S Bazeley Anwar B Beshir Gabriel Fenteany Rohit Mehra Stephanie Daignault Fahd Al-Mulla Evan Keller Ben Bonavida Ivana de la Serna Kam C Yeung

Epigenetic modifications such as histone methylation play an important role in human cancer metastasis. Enhancer of zeste homolog 2 (EZH2), which encodes the histone methyltransferase component of the polycomb repressive complex 2 (PRC2), is overexpressed widely in breast and prostate cancers and epigenetically silences tumor suppressor genes. Expression levels of the novel tumor and metastasis...

2015
Chang Liu Shuai Li Xiaoyan Dai Ji Ma Junhu Wan Hao Jiang Peng Wang Zhaoli Liu Hongquan Zhang

Polycomb repression complex 2 (PRC2) component EZH2 tri-methylates H3K27 and exerts epigenetic repression on target gene expression. EZH2-mediated epigenetic control of RNA polymerase II (Pol II) transcribed coding gene transcription has been well established. However, little is known about EZH2-mediated epigenetic regulation of RNA polymerase III (Pol III) transcription. Here we present a para...

Journal: :Molecular cancer research : MCR 2014
Gauri Deb Anup Kumar Singh Sanjay Gupta

Seminal discoveries have established that epigenetic modifications are important for driving tumor progression. Polycomb group (PcG) proteins are highly conserved epigenetic effectors that maintain, by posttranslational modification of histones, the silenced state of genes involved in critical biologic processes, including cellular development, stem cell plasticity, and tumor progression. PcG p...

2013
Yung-Luen Yu Kuo-Jung Su Yi-Hsien Hsieh Hsiang-Lin Lee Tzy-Yen Chen Pei-Ching Hsiao Shun-Fa Yang

BACKGROUND The enhancer of zeste 2 (EZH2) gene encodes the histone methyltransferase that is the catalytic component of the polycomb repressive complex-2, which initiates epigenetic silencing of genes. The expression level of EZH2 in hepatocellular carcinoma (HCC) is highly correlated with tumor progression; however, it has not been determined if specific EZH2 genetic variants are associated wi...

2013
Zhongwu Li Yanling Wang Jing Qiu Qiang Li Chunping Yuan Wei Zhang Dongmiao Wang Jinhai Ye Hongbin Jiang Jianrong Yang Jie Cheng

EZH2, a core member of the Polycomb Repressor Complex 2 (PRC2), mediates transcriptional silencing by catalyzing the trimethylation of histone 3 lysine 27 (H3K27), which plays key roles in cancer initiation and progression. Here, we investigated the expression pattern and biological roles of EZH2 in tongue tumorigenesis by loss-of-function assays using small interference RNA and EZH2 inhibitor ...

2011
Maria E. Gonzalez Matthew L. DuPrie Heather Krueger Sofia D. Merajver Alejandra C. Ventura Kathy A. Toy Celina G. Kleer

Increased levels of EZH2, a critical regulator of cellular memory, signal the presence of metastasis and poor outcome in breast cancer patients. High levels of EZH2 are associated with nuclear pleomorphism, lack of estrogen receptor expression, and decreased nuclear levels of BRCA1 tumor suppressor protein in invasive breast carcinomas. The mechanism by which EZH2 overexpression promotes the gr...

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