نتایج جستجو برای: ژن pgc

تعداد نتایج: 19502  

Journal: :Journal of Functional Foods 2021

The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function the hippocampus. Type diabetic rats and controls were assigned following groups for 16 weeks: Control + Water; GA 10% w/v; Diabetes w/v. Latency water maze shorter compared Water (P < 0.05). group had a higher expression density per cell p...

Journal: :European heart journal. Cardiovascular pharmacotherapy 2016
Candace Y W Lee Brenda K Huntley Daniel J McCormick Tomoko Ichiki S Jeson Sangaralingham Ondrej Lisy John C Burnett

AIMS Cenderitide is a novel dual natriuretic peptide (NP) receptor chimeric peptide activator, which targets the particulate guanylyl cyclase B (pGC-B) receptor and pGC-A unlike native NPs. Cenderitide was engineered to retain the anti-fibrotic properties of C-type natriuretic peptide (CNP)/pGC-B with renal-enhancing actions facilitated by fusion to the carboxyl terminus of Dendroaspis NP (DNP)...

Journal: :International journal of clinical and experimental pathology 2015
Hui Peng Wenyu Zhong Hong Zhao Li Chen Xiao Zhou Feng Li Weiwei Zhu Guimei Li

Endothelial cells (ECs) apoptosis induced by hyperglycemia is intimately involved in the pathophysiology of diabetes and its complication. Although PGC-1α is known for its role in glucose metabolism, its role in ECs injury caused by high glucose milieu is still unclear. Therefore, this study aims to investigate whether PGC-1α participates in ECs apoptosis under high glucose condition. Human umb...

Journal: :Developmental biology 1986
Kathleen Molyneaux Christopher Wylie

Mutational and antisense screens in Drosophila and zebrafish, and transcriptional profiling and time-lapse analysis in the mouse, have contributed greatly to our understanding of PGC development. In all three systems, the behavior of PGCs is controlled by growth factors which signal through G-protein coupled receptors and/or tyrosine kinase receptors. Additionally, regulated cell-cell and cell-...

2013
Veronika Preylowski Susanne Schlögl Frédéric Schoenahl Gerhard Jörg Samuel Samnick Andreas K. Buck Michael Lassmann

OBJECTIVES The aim of this study is to evaluate the quality of I-124 PET images with and without prompt gamma compensation (PGC) by comparing the recovery coefficients (RC), the signal to noise ratios (SNR) and the contrast to F-18 and Ga-68. Furthermore, the influence of the PGC on the quantification and image quality is evaluated. METHODS For measuring the image quality the NEMA NU2-2001 PE...

2012
Jesper Olesen Signe Larsson Ninna Iversen Simi Yousafzai Ylva Hellsten Henriette Pilegaard

Many lifestyle-related diseases are associated with low-grade inflammation and peroxisome proliferator activated receptor γ coactivator (PGC)-1α has been suggested to be protective against low-grade inflammation. However, whether these anti-inflammatory properties affect acute inflammation is not known. The aim of the present study was therefore to investigate the role of muscle PGC-1α in acute...

2016
Tashinga E. Bapiro Frances M. Richards Duncan I. Jodrell

Porous graphitic carbon (PGC) is an important tool in a chromatographer's armory that retains polar compounds with mass spectrometry (MS)-compatible solvents. However, its applicability is severely limited by an unpredictable loss of retention, which can be attributed to contamination. The solutions offered fail to restore the original retention and our observations of retention time shifts of ...

Journal: :Journal of neuropathology and experimental neurology 2012
Nadine Thau Sarah Knippenberg Sonja Körner Klaus Jan Rath Reinhard Dengler Susanne Petri

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motoneuron loss. Although the cause of ALS is unknown, oxidative stress, inflammation, and mitochondrial dysfunction have been identified as important components of its pathogenesis. Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) plays a central role in the regulation of mit...

2012
Joshua T. Selsby Kevin J. Morine Klara Pendrak Elisabeth R. Barton H. Lee Sweeney

Increased utrophin expression is known to reduce pathology in dystrophin-deficient skeletal muscles. Transgenic over-expression of PGC-1α has been shown to increase levels of utrophin mRNA and improve the histology of mdx muscles. Other reports have shown that PGC-1α signaling can lead to increased oxidative capacity and a fast to slow fiber type shift. Given that it has been shown that slow fi...

2015
Hong-Jhih Jhuang Wei-Hsiang Hsu Kuan-Ting Lin Shih-Lan Hsu Feng-Sheng Wang Chen-Kung Chou Kuen-Haur Lee Ann-Ping Tsou Jin-Mei Lai Sheau-Farn Yeh Chi-Ying F. Huang

PGC-1α, a major metabolic regulator of gluconeogenesis and lipogenesis, is strongly induced to coactivate Hepatitis B virus (HBV) gene expression in the liver of fasting mice. We found that 8-Br-cAMP and glucocorticoids synergistically induce PGC-1α and its downstream targets, including PEPCK and G6Pase. Also, HBV core promoter activity was synergistically enhanced by 8-Br-cAMP and glucocortico...

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