It was reported that statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase that are used to prevent hypercholesterolemia, have antitumor activity in several cancers. In this study, we investigated the cell viability of statins in Cisplatin-resistant HCP4 and PCDP5 cells compared with their parent Hela and PC3 cells, respectively, and found that HCP4 and PCDP5 cells were 37-fold...

A long-standing goal in cancer research is to identify cellular functions that have selective roles in regulating neoplastic pathophysiology. Farnesyl-transferase inhibitors (FTIs) are a novel class of cancer chemotherapeutics which have little effect on normal cell physiology but which inhibit or reverse malignant cell phenotypes. FTIs were originally developed as a strategy to inhibit oncogen...

Evaluating any subsurface CO2 storage site comprises the reservoir, seal, and overburden investigation to mitigate injection storage-related complications. The Upper-Middle Jurassic Sognefjord, Fensfjord, Krossfjord formation sandstones are potential reservoirs at Smeaheia area, northern North Sea. area is located east of Troll oil gas field. Upper organic-rich Heather Draupne Formation shales ...

[This corrects the article DOI: 10.1371/journal.pone.0172125.].

The P10 well is located offshore, in the Northern part of Rio Del Rey basin southwest Cameroon. Although most prolific coastal Cameroon given production results from several fields southern part, yet it remains very little explored its northern part. This work evaluation petroleum potential Basin using a combination "Quick Look" interpretation logs recorded and "compl...

Nogo-A is an oligodendroglial neurite outgrowth inhibitor, the deactivation of which enhances brain plasticity and functional recovery in animal models of stroke. Nogo-A's role in the reperfused brain tissue was still unknown. By using Nogo-A(-/-) mice and mice in which Nogo-A was blocked with a neutralizing antibody (11C7) that was infused into the lateral ventricle or striatum, we show that N...

The neural crest is a migratory cell population that gives rise to multiple cell types in the vertebrate embryo. The intrinsic determinants that segregate neural crest cells from multipotential dorsal progenitors within the neural tube are poorly defined. In this study, we show that the winged helix transcription factor Foxd3 is expressed in both premigratory and migratory neural crest cells. F...