We describe a quantitative assay of transendothelial migration (TEM) that allows us to selectively study the interaction of monocytes with confluent human endothelial cell (HEC) monolayers. The HEC are grown on hydrated collagen gels; the monocytes need not be purified. 100% of monocytes transmigrated the monolayer within 1 h at 37~ and accumulated in the subendothelial collagen; TEM oflymphocy...

In this paper, we propose the HEC-PF scheme, an enhancement of our previous H-EC scheme for effective data forwarding in opportunistic networks. The enhanced scheme modifies the aggressive forwarding phase of the H-EC scheme by implementing a new Probabilistic Forwarding feature, which decides whether to forward a message to a newly encountered node based on the delivery probability. Using simu...

Tamoxifen (TAM), used to treat estrogen receptor (ER)-positive breast cancer, is a well known estrogen antagonist in the breast, but a partial estrogen agonist in the endometrium. In addition, TAM metabolites, such as 4'-hydroxy-tamoxifen (4-OH-TAM), have been shown to be more potent than the parent compound. The objective of this study was to determine the effects of 4-OH-TAM and estradiol (E2...

Spyridon Orestis Palermos This paper focuses on the hypothesis of the extended cognition (HEC), and in particular, on two interrelated objections to it, namely the coupling-constitution fallacy and the cognitive bloat worry. Briefly, if there is no principled way in which we can decide whether a (cognitive) process depends on extra-neural (or extra-organismic) factors in a causal, or constituti...

A geographic information system ~GIS! based approach is presented for the development of a terrain model based on stream channel representation of the U. S. Army Corps of Engineers Hydrologic Engineering Center’s River Analysis System ~HEC-RAS! hydraulic model. As input, the approach requires a completed HEC-RAS simulation, a digital elevation model ~DEM!, and a GIS representation of the stream...

The smectites represent a versatile class of clay minerals with broad usage in industrial applications, e.g., cosmetics, drug delivery, bioimaging, etc. Synthetic hectorite Na0.7(Mg5.5Li0.3)[Si8O20](OH)4 is a distinct material from this class due to its low-cost production method that allows to design its structure to match better the applications. In the current work, we have synthesized for t...

BACKGROUND The aim of this study was to investigate the sensitivity to rapamycin of endometrial cancer cells with different phosphatase and tensin homologue (PTEN) expression to understand the mechanism of resistance to mammalian target of rapamycin (mTOR) inhibitors in the treatment of endometrial cancer. MATERIAL AND METHODS Twenty specific pathogen-free female BALB/c mice received transpla...

BACKGROUND Safe, effective and convenient antiemetic regimens that preserve benefit over repeated cycles are needed for optimal supportive care during cancer treatment. NEPA, an oral fixed-dose combination of netupitant, a highly selective NK1 receptor antagonist (RA), and palonosetron (PALO), a distinct 5-HT3 RA, was shown to be superior to PALO in preventing chemotherapy-induced nausea and vo...

OBJECTIVE We compared profiles of the numbers of circulating endothelial cells (CEC) and the apoptosis-inducing capacity of serum samples on human endothelial cells (hEC) in on-pump and off-pump coronary artery bypass grafting (CABG) patients. METHODS Blood samples from 30 patients undergoing CABG (randomly assigned to two groups: 15 patients off-pump and 15 on-pump (cardiopulmonary bypass, C...