Direct evidence for the requirement of delay in feedback repression in the mammalian circadian clock has been elusive. Cryptochrome 1 (Cry1), an essential clock component, displays evening-time expression and serves as a strong repressor at morning-time elements (E box/E' box). In this study, we reveal that a combination of day-time elements (D box) within the Cry1-proximal promoter and night-t...

Abstract Given a finite set of weighted points in $${\mathbb {R}}^d$$ R d (where there can be negative weights), the maximum box problem asks for an axis-aligned rectangle (i.e., box) such that sum weights it contains is maximized. We consider eac...

An axis parallel d-dimensional box is the Cartesian product R1×R2×· · ·×Rd where each Ri is a closed interval on the real line. The boxicity of a graph G, denoted as box(G), is the minimum integer d such that G can be represented as the intersection graph of a collection of d-dimensional boxes. An axis parallel unit cube in d-dimensional space or a d-cube is defined as the Cartesian product R1 ...

D. Haberer,1,2 L. Petaccia,3 A. V. Fedorov,1,4 C. S. Praveen,5 S. Fabris,5 S. Piccinin,5 O. Vilkov,4,6 D. V. Vyalikh,4,6 A. Preobrajenski,7 N. I. Verbitskiy,8,9 H. Shiozawa,8 J. Fink,1 M. Knupfer,1 B. Büchner,1 and A. Grüneis1,8 1IFW Dresden, P. O. Box 270116, D-01171 Dresden, Germany 2Department of Physics, University of California at Berkeley, Berkeley, California 94720, USA 3Elettra Sincrotr...

Surfactant protein D (SP-D) plays roles in pulmonary host defense and surfactant homeostasis and is increased following lung injury. Because AP-1 proteins regulate cellular responses to diverse environmental stimuli, we hypothesized that the conserved AP-1 motif (at -109) and flanking sequences in the human SP-D promoter contribute to the regulation of SP-D expression. The AP-1 sequence specifi...

D. Y. Lin,’>’>* P. Arbogast,’)’ D. S. S i ~ c o v i c k , ~ ~ ~ and R. N. Lemaitre’ IDepartment of Biostatistics, Box 357232, University of Washington, Seattle, Washington 98195, U.S.A. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 9810 1, U . S. A. 3Department of Epidemiology, Box 357236, University of ...

Functional programming has inherent parallel features. This situation can be exploited by building different language constructs for parallel and distributed programming. Earlier we designed two languages for skeleton based distributed functional programming on a cluster. The two languages have different expressive power and abstraction levels. Our distributed functional computation is based on...

The 15.5K protein directly binds to the 5' stem-loop of the U4 small nuclear RNA, the small nucleolar (sno) RNA box C/D motif, and the U3 snoRNA-specific box B/C motif. The box B/C motif has also been shown to be essential for the association of the U3 small nucleolar ribonucleoprotein-specific protein hU3-55K. We therefore set out to determine how 15.5K and hU3-55K recognize the box B/C motif....

An axis-parallel d–dimensional box is a Cartesian product R1 × R2 × · · · × Rd where Ri (for 1 ≤ i ≤ d) is a closed interval of the form [ai, bi] on the real line. For a graph G, its boxicity box(G) is the minimum dimension d, such that G is representable as the intersection graph of (axis–parallel) boxes in d–dimensional space. The concept of boxicity finds applications in various areas such a...