Interleukin 28B (IL28B) rs12979860 polymorphisms were examined in 41 individuals with human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis than in 29 asymptomatic carriers (80% vs 20%; P = .03), and median HTLV-1 proviral load was greater in CT/TT than CC carriers (P = .01). Thus, IL28B...

The best arm identification problem (BEST-1-ARM) is the most basic pure exploration problem in stochastic multi-armed bandits. The problem has a long history and attracted significant attention for the last decade. However, we do not yet have a complete understanding of the optimal sample complexity of the problem: The state-of-the-art algorithms achieve a sample complexity of O( ∑n i=2 ∆ −2 i ...

In this paper we consider the reconstruction problem on the tree for the hardcore model. We determine new bounds for the non-reconstruction regime on the k-regular tree showing non-reconstruction when λ < (ln 2 − o(1)) ln k 2 ln ln k improving the previous best bound of λ < e − 1. This is almost tight as reconstruction is known to hold when λ > (e+ o(1)) ln k. We discuss the relationship for fi...

OBJECTIVE To evaluate the effectiveness of liquid nitrogen (LN(2)) vapor (indirect contact method) for the storage of human semen. DESIGN Experimental study. SETTING University hospital-based fertility center. PATIENT(S) We evaluated 150 patients with normal sperm parameters. INTERVENTION(S) Human semen (N = 120) was mixed with Semen Freezing Medium, divided into two groups, frozen, and...

Embryonic retinal neurons lose the ability to extend neurites on laminin-1 (LN-1) with increasing developmental age yet still do so on other laminin isoforms. However, after treatment of LN-1 with antibodies to "short-arm" regions or removal of the short arms proteolytically, LN-1 supports attachment and extension of neurites even by late embryonic retinal neurons. We have mapped a domain for a...

Abstract Synthesis and structural characterization of two heterodinuclear Zn II -Ln III complexes with the formula [ZnLn(HL)(µ-OAc)(NO 3 ) 2 (H O) x (MeOH) 1-x ]NO · n H O MeOH [Ln = Pr ( 1 ), Nd )] crystal molecular structure [ZnNd(HL)(µ-OAc)(NO O)] [ZnNd(HL)(OAc)(NO O)](NO are reported. The asymmetrical compartmental ligand E )-2-(1-(2-((2-hydroxy-3-methoxybenzylidene)amino)-ethyl)imidazolidi...

BACKGROUND Management of lupus nephritis (LN) would be greatly aided by the discovery of biomarkers that accurately reflect changes in disease activity. Here, we used a proteomics approach to identify potential urinary biomarkers associated with LN. METHODS Urine was obtained from 60 LN patients with paired renal biopsies, 25 active non-LN SLE patients, and 24 healthy controls. Using Luminex,...

Background: Atherosclerosis is a chronic inflammation that interferes with blood arteries functions due to the accumulation of low density lipids and cholesterol. Objective: To investigate the effect of aqueous extract and saponin fraction of Tribulus terrestris L. (TT) on the proteome and expression of intracellular adhesion molecule-1 (ICAM-1), vascu...

Anionic lanthanide chloride clusters, Ln(n)Cl(3n+1)(-), were produced by electrospray ionization (ESI) of LnCl(3) in isopropanol, where Ln = La-Lu (except Pm); the clusters were characterized using a quadrupole ion trap mass spectrometer. High-abundance "magic number" clusters were apparent at n = 4 for the early Ln (La-Sm), and at n = 5 for the late Ln (Dy-Lu). Density functional theory comput...

Immunization with pneumococcal polysaccharides (PPS) conjugated to tetanus toxoid (TT) (Pnc-TT) elicits protective immunity in an adult murine pneumococcal infection model. To assess immunogenicity and protective immunity in early life, neonatal (1 week old) and infant (3 weeks old) mice were immunized intranasally (i.n.) or subcutaneously (s.c.) with Pnc-TT of serotype 1 (Pnc1-TT). Anti-PPS-1 ...