INTRODUCTION The use of protease inhibitors (PI) has led to a decrease in HIV-1-related mortality and morbidity. The objective of this study was to collect safety data on treatment with fosamprenavir/ritonavir (FPV/r) 700/100mg BID in HIV-infected patients through an expanded access program. PATIENTS AND METHODS Prospective, multicenter, noncomparative study in HIV-1 infected adults, for whom...

Trimethoprim, which has been widely available for several years in combination with sulphamethoxazole as co-trimoxazole, is now available for use alone in the treatment of acute uncomplicated urinary tract infections. Trimethoprim, which is active against a wide range of Gram-positive and Gram-negative aerobic bacteria, is readily absorbed by the oral route and is widely distributed in body flu...

PURPOSE Seizures and antiepileptic drugs (AED) may disrupt sleep patterns in patients with epilepsy, thus evaluation of lacosamide effects on objective and subjective sleep measures is warranted. METHODS A multicenter, interventional, open-label study (NCT01530386) was conducted in healthy subjects without confounding effects of concomitant AED use, co-morbidities, or disease state to determi...

One of the most common disorders of the endocrine system is diabetes mellitus. This disease is associated with dyslipidemia. Adiponectin is a protein hormone that secreted by adipocytes and has an important role in regulating of glucose and fatty acid metabolic pathways. This study was designed to investigate the changes in serum level of adiponectin in diabetic rats treated with hydroalcoholic...

A total of two hundred and seventy day-old Arbor Acre strain of broiler chicks were used for this research. Five treatment: T1 positive control (10 birds/m), T2 negative control, T3, T4 and T5 had 20 birds/m. T1 and T2 had no supplementation with vitamin E (d1-α-tocopheryl acetate). T3, T4 and T5 had 50mg/kg, 100mg/kg and 150 mg/kg vitamin E supplementations respectively. Feed intake, feed conv...

Cardiovascular diseases form the major health concern in recent years, causing severe illness and death throughout the world. About 16.7 million people around the globe die of myocardial infarction every year (WHO 2004) which forms one third of global deaths. Clinically, taurine has been widely used in variety of conditions including cardiovasculardiseases, hypercholesterolemia, macular degener...

Pyrexia and inflammation are indicatives of various disorders. Modern medicines are available for treatment of pyrexia, but they have few side effects. Several studies are ongoing Worldwide to search natural antipyretic agents with better efficacy and fewer or no side effects. This study was aimed at evaluating the antipyretic activity of Moringa oleifera bark in rabbits against E. coli induced...

BACKGROUND Mortality in dialysis patients remains high and is due mainly to cardiovascular causes. Inflammation has a role in the genesis of accelerated atherosclerosis, vascular calcification, malnutrition and anemia, and a huge impact on the survival of these patients. The pleiotropic effects of statins can be a therapeutic option for reducing chronic inflammatory processes of patients underg...

PURPOSE We compared the effects of local levobupivacaine infiltration, intravenous paracetamol, intravenous lornoxicam treatments on postoperative analgesia in patients submitted to transperitoneal laparoscopic renal and adrenal surgery. MATERIALS AND METHODS Sixty adult patients 26 and 70 years who underwent laparoscopic renal and adrenal surgery were randomized into three groups with 20 pat...

To estimate phenols and flavonoids, enzymic antioxidants in the leaves of Boerhaavia erecta (LBE). The sample was extracted with 0.1M phosphate buffer for the analysis of phenols, flavonoids and antioxidants. The total phenolic content and total flavonoids in LBE were measured using Folin-Ciocalteau and aluminium chloride colorimetric methods respectively. The activity of Superoxide Dismutase (...