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The case histories of 293 adolescent and adult patients with acute lymphoblastic leukemia (ALL) first seen and treated between 1969 and 1979 are reviewed. A complete remission (CR) was achieved in 79% of cases. Male sex, advanced age (greater than or equal to 30 yr old), and early CNS involvement were the major determinants of remission failure. Median duration of first CR was 16 mo, with 23 pa...
Detailed data on the physiological pattern of adrenocortical activity during normal growth are lacking. An established method to determine adrenocortical glucocorticoid secretion is the measurement of 24-h excretion rates of major urinary cortisol metabolites (C21). To test the hypothesis that the frequently reported higher cortisol secretion in men than in women develops during puberty, we exa...
Obesity has become a pandemic, with more than a billion people affected worldwide (1). Over the past 30 yr, the frequency of overweight children, defined as a body mass index (BMI) greater than the 85th percentile for age and sex, has tripled (2). More than 30% of children in the United States are overweight or obese (BMI 95th percentile) (3). Data from the International Obesity Task Force indi...
Small pancreatic cancers (longest diameter </=2 cm) have been regarded as preliminary to early pancreatic cancer, which was thought to be highly curable. During our experience since 1989, we evaluated 542 cases of pancreatic cancer. Among them we found 74 cases of tumors </=2 cm in diameter, small pancreatic cancer (TS1 pancreatic cancer). Well-differentiated adenocarcinomas (18.9%) and absence...
Demography provides critical data to increase our understanding of the evolution, ecology, and conservation of primate populations. The chimpanzees of the Mahale Mountains National Park, Tanzania, have been studied for more than 34 yr on the basis of individual identification and standardized attendance records. From this long-term study, we derived the following demographic data: The major cau...
Abstract Proposed next-generation networks of gravitational-wave observatories include dedicated kilohertz instruments that target neutron star science, such as the proposed Neutron Star Extreme Matter Observatory, NEMO. The original proposal for NEMO highlighted need it to exist in a network ensure detection confidence and sky localisation sources. We show NEMO-like have significant utility on...
Reforestation in the tropics is highlighted as an important intervention to mitigate climate change globally because of its potential for high CO2 removal rates, ranging from 4.5 40.7 t CO2e ha?1 yr?1 during first 20 years tree growth. critical meeting emissions’ targets Paris Climate Agreement, well achieving Indonesia’s Nationally Determined Contribution (NDC) targets. Increasing carbon stock...
In its long-duration observation phase, the PLATO satellite will observe two non-overlapping fields for a total of 4 yr. The exact duration each pointing be determined 2 yr before launch. Previous estimates PLATO's yield Earth-sized planets in habitable zones (HZs) around solar-type stars ranged between 6 and 280. We use Solar-like Light curve Simulator (PSLS) to simulate light curves with tran...
Primary meningeal sarcoma is a rare tumor in pediatric age group. Here we were reporting an extremly rare case report of an 11 year old boy presented with quadriparesis and bladder involvement. MRI revealed a cervical dural based tumor with extension to cord parenchyma and neural foramina involving paravertebral tissue. The histopathology revealed mesenchymal tumor with malignant potential whic...
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