Tacrine (THA) and physostigmine (PHS) have been used in Alzheimer's disease therapy for their anticholinesterasic activity. Here we show that THA is taken up in rat lysosomes in an energy-dependent manner, and that it is also accumulated in acidic compartments of rat thymocytes and neuroblastoma cells. A concentration of THA less than 1 mM dissipated the pH gradient (delta pH) in all the above ...

Total hip arthroplasty (THA) has been shown to be highly effective in ameliorating pain and increasing function in adults with end stage arthritis of the hip. Early studies of cemented THA in children with advanced hip disease reported poor results, but, more recently, results of cementless THA show greatly improved outcomes. More recently, concerns related to THA in children have focused on we...

PURPOSE Periprosthetic joint infection (PJI) after total hip arthroplasty (THA) is a grave complication. Urinary tract infection (UTI) as a source for PJI is controversial. Our purposes were, (1) to evaluate the incidence of PJI after elective primary THA and (2) to determine whether UTI was associated with a risk of PJI after elective primary THA. MATERIALS AND METHODS We retrospectively rev...

PURPOSE It remains controversial whether mini-incision (MI) benefits patients in total hip arthroplasty (THA). We performed a meta-analysis of randomized controlled trials (RCTs) to assess the effects of MI on surgical and functional outcomes in THA patients. METHODS A systematic electronic literature search (up to May 2013) was conducted to identify RCTs comparing MI with standard incision (...

BACKGROUND Demand for total hip arthroplasty (THA) is high and expected to continue to grow during the next decade. Although much of this growth includes working-aged patients, cost-effectiveness studies on THA have not fully incorporated the productivity effects from surgery. QUESTIONS/PURPOSES We asked: (1) What is the expected effect of THA on patients' employment and earnings? (2) How doe...

Abstract Operative time is a potential modifiable target for reducing cost and optimizing efficiency in total hip arthroplasty (THA). Shorter operative times are associated with decreased costs complications. One proposed solution operating room (OR) to preferentially perform THAs at higher volume center. The purpose of this study investigate the impact different hospital settings on mean THA. ...

BACKGROUND Coxofemoral osteoarthritis is a chronic, disabling condition affecting people and dogs, with THA providing an excellent return to function in severely affected joints. The principal role of THA is to restore an adequate range of motion to the hip joint while transferring load from the acetabulum in order to improve the survival of the implant and enhance the limb function in the shor...

OBJECTIVE The study hypotheses were that: (i) there would be a difference in sagittal plane alignment between patients with symptomatic osteoarthritis of the hip and those with lumbar degenerative disk disease; and (ii) that sagittal plane lumbar alignment would change following total hip arthroplasty (THA). METHODS In this prospective study, a series of patients without back pain or lumbar c...