In a genome-wide search, linkage of hypokalemic periodic paralysis (HypoPP), a muscle disease with autosomal dominant inheritance, to chromosome 1q31-32 and cosegregation with the gene encoding the L-type calcium channel/DHP receptor alpha 1 subunit has been reported (Fontaine et al., 1994). Here we show the extended haplotypes of a large HypoPP family who made the detection of the gene product...

PURPOSE To directly compare and study the variability of parameters related to hepatic blood flow measurements using 3 T phase-contrast magnetic resonance imaging (PC-MRI) and Doppler ultrasound (US). MATERIALS AND METHODS Nine healthy subjects were studied. Blood velocities and flow rate measurements were performed in the portal vein and the proper hepatic artery. MR studies were performed u...

BACKGROUND Osteoporotic fractures are important causes of morbidity, mortality, and increased health care costs. However, the risk of osteoporotic fractures can be decreased, with clinical studies supporting the use of calcium and vitamin D supplements to promote bone health. Vitamin D insufficiency is widespread, particularly among postmenopausal women with osteoporosis, and this indicates tha...

In this work, we report on a simple and scalable process to synthesize the core-shell nanostructure of MoS2@N-doped carbon nanosheets (MoS2@C), in which polydopamine is coated on the MoS2 surface and is then carbonized. An intensive investigation using transmission electron microscopy and Raman spectroscopy reveals that the as-synthesized MoS2@C possesses a nanoscopic and ultrathin layer of MoS...

OBJECTIVES We evaluated outcomes in couples treated for infertility with natural procreative technology (NaProTechnology [corrected] NPT), a systematic medical approach for optimizing physiologic conditions for conception in vivo, from an Irish general practice. METHODS All couples receiving treatment from 2 NPT-trained family physicians between February 1998 and January 2002 were studied. Th...

Drug-induced immune thrombocytopenia is caused by drug-dependent antibodies (DDAbs) that bind tightly to platelet glycoproteins only when drug is present. How drugs mediate this interaction is not yet resolved. Several studies indicate that sites recognized by DDAbs tend to cluster in specific structural domains, suggesting they may recognize a limited number of distinct epitopes. To address th...

A growing body of research suggests that perceived discrimination, in multiple societies, is a neglected but important predictor of increased risk of disease for a broad range of health status indicators. Several prior studies propose that discrimination is adversely related to increased cardiovascular disease risk. The studies by Hunte (Am J Epidemiol. 2011;173(11):1223-1231) and Lewis et al. ...

OBJECTIVE To describe trends in the proportion of US hospitals that distribute industry-sponsored formula sample packs between 2007 and 2010. METHODS This is a follow-up of a 2007 study. In 2007, we surveyed all 50 US states to determine the proportion of hospitals that distributed infant formula samples to new mothers. In 2010, we selected the 10 best-record and 10 worst-record states with r...

A positive family history is recognized as an important risk factor for type 2 diabetes mellitus (T2DM), but the association of family history with rennin-angiotensin system (RAS) gene polymorphisms has not been reported yet, thus we aim to investigate it.Family history records, clinical and biochemical data were obtained from 1239 T2DM patients. Polymerase chain reaction (PCR) was performed fo...

4288 The Journal of Clinical Investigation http://www.jci.org Volume 122 Number 11 November 2012 1. Robbins DC, Tager HS, Rubenstein AH. Biologic and clinical importance of proinsulin. N Engl J Med. 1984;310(18):1165–1175. 2. Steiner DF, Rubenstein AH. Recent studies on the biosynthesis, secretion and metabolism of proinsulin and C-peptide. In: Musacchia XJ, Breitenbach RP, eds. Proceedings of ...