Developmental exposure of Long-Evans rats to 0, 1, 4, or 8 mg/kg/day Aroclor 1254 (A1254) from Gestational Day 6 through Postnatal Day 21 produces an elevated behavioral threshold for a 1-kHz tone. Brainstem auditory evoked responses (BAERs) were assessed in a subset of these animals (about 1 year old) using filtered clicks at 1 (65 and 80 dB SPL), 4 (60 and 80 dB SPL), 16 (40 and 80 dB SPL), a...

Polychlorinated biphenyls (PCBs) have been found in fish and wildlife from many parts of the world at levels which may adversely affect aquatic organisms and interfere with pesticide residue analyses (1, 2, 3, 4). The environmental occurrence, uses, and present toxicological aspects of PCBs were recently reviewed by Peakall and Lincer (5), Gustaffson (6), and Risebrough (7). PCBs have gas chrom...

Context We have isolated five stable clones from a primary culture of Syrian golden hamster pancreatic duct epithelial cells and have designated them as CK1 through CK5. Design Here we describe the ability of two of these, CK1 and CK5, to metabolize the pancreas carcinogen N-nitrosobis(2oxopropyl)amine. The metabolism was assessed as the production of mutated V79 cells in a CK cell/V79 co-cultu...

Dibenz(a,h)anthracene (DBA), a carcinogenic, polycyclic aromatic hydrocarbon ubiquitous in the environment, is metabolized by the hepatic microsomal fraction of immature Sprague-Dawley rats pretreated with Aroclor 1254 to 27 ethyl acetate-extractable metabolites. More than half of these metabolites (51%) consisted of trans-1,2-; -3,4-; and -5,6-dihydrodiols including their identified secondary ...

The time is right to transition telerobotics beyond the traditional hazardous environment domain into industrial repair and remanufacturing applications. Air Force depots are prime examples of an industrial environment where small batch sizes, feature uncertainty, and varying workload, conspired to make classical industrial robotic solutions impractical and telerobotics a key enabling technolog...

Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and have been detected in human blood, adipose tissue, and breast milk. Developmental and long-term exposures to these contaminants may pose a human health risk, especially to children. Previously, we demonstrated that polychlorinated biphenyls (PCBs), which are neurotoxic and structurally similar to PBDEs, perturbed int...