Methionine synthase catalyzes the remethylation of homocysteine to methionine in a methylcobalamin-dependent reaction. We used specific regions of homology within the methionine synthase sequences of several lower organisms to clone a human methionine synthase cDNA by a combination of RT-PCR and inverse PCR. The enzyme is 1265 amino acids in length and contains the seven residue structure-based...

1. Wisner DM, Quillen DA, Benderson DM, Green MJ. Patient attitudes toward resident involvement in cataract surgery. Arch Ophthalmol. 2008;126(9):12351239. 2. Vallance JH, Ahmed M, Dhillon B. Cataract surgery and consent: recall, anxiety, and attitude toward trainee surgeons preoperatively and postoperatively. J Cataract Refract Surg. 2004;30(7):1479-1485. 3. Versluis MA, van der Linden PJ. Pat...

s published: Xuejing Zhang, Man-Tzu Wang, Yong Tang, Yakun Chen, and Daotai Nie. Thromboxane A2 receptor (TP) in tumor cell motility and metastasis. Proc. Amer. Assoc. Cancer Res. 48: #3098, 2009. Grants submitted: Xuejing Zhang (PI), Daotai Nie (mentor). Aspirin, Thromboxane, and Breast Cancer Metastasis. Department of Defense Breast Cancer Research Program Predoctoral Training Grants. Article...

Results The total number of reported ADRs increased from 420 to 1265. The most common ADR reporters were doctors (59.4%), followed by nurses (29.4%) which was significantly increased from 2012 (8.8%). The most common causative drugs were antibiotics (30.6%), followed by miscellaneous drugs (30.4%), and antituberculosis drugs (10%), and clinical manifestations of ADRs were cutaneous (41.9%), gas...

The assembly of local communities is the result of the tension between local, often negative, and possibly deterministic interactions, and larger-scale environmental or dispersal constraints or stochastic events (Berlow, 1997; Levine, 2000; Lovette & Hochachka, 2006). Larger-scale environmental conditions and dispersal limitation filter a larger pool of potential colonists into one that include...

Peregrine Laziosi (1265-1345), an Italian priest, became the patron saint of cancer patients when the tumour in his left leg miraculously disappeared after he developed a fever. Elevated body temperature can cause tumours to regress and sensitizes cancer cells to agents that break DNA. Why hyperthermia blocks the repair of broken chromosomes by changing the way that the DNA damage checkpoint ki...

We examine physicists’ charge of adhocness against the Higgs mechanism in the Standard Model of elementary particle physics. We argue that even though this charge never rested on a clear-cut and well-entrenched definition of “ad hoc”, it is based on conceptual and methodological assumptions and principles which are well-founded elements of the scientific practice of high-energy particle physics...

The presence of inducible nitric oxide synthase (iNOS) in fresh monocytes from patients with Graves' disease was demonstrated for the first time. Immunophenotypic analysis showed a profile reflecting a state of activation and differentiation of monocytes. Incubation of lymphomononuclear cells from healthy volunteers in the presence of synthetic peptides with sequences related to thyroid autoant...