Our previous studies have suggested a protective role for H. pylori infection in the prognosis of gastric cancer. Based on those findings, we hypothesized that H. pylori-positive and -negative gastric cancers may exhibit different growth patterns and pathobiological behaviors, indicating different mechanisms of cancer progression. By microarray analysis, we studied miRNAs expression profiles in...

A common characteristic of aging is defective regeneration of skeletal muscle. The molecular pathways underlying age-related decline in muscle regenerative potential remain elusive. microRNAs are novel gene regulators controlling development and homeostasis and the regeneration of most tissues, including skeletal muscle. Here, we use satellite cells and primary myoblasts from mice and humans an...

BACKGROUND & AIMS TGF-β1 is an abundant cytokine present in the tumour microenvironment. It has been shown to trigger versican expression in human osteosarcoma cells, which may account for the metastatic potential of these cells. However, the underlying mechanism of TGF-β1-mediated metastasis remains unclear. The aim of this study was to evaluate the roles of versican in TGF-β1-induced osteosar...

Hand eczema (HE) is a highly prevalent chronic disease affecting 15% of the population. Clinical grading systems are time-intensive and require training, making overall coarse assessment default approach in practice. We present an image-based deep learning method to automatically evaluate HE lesion surface determine their anatomical repartition. This retrospective study was based on two dataset...

AMA Oskędra I, Wojtas K, Szarek A. Social media as a source of knowledge ab out health nursing students. Nursing Problems / Problemy Pielęgniarstwa. 2022;30(4):143-148. doi:10.5114/ppiel.2022.126824. APA Oskędra, I., Wojtas, K., & Szarek, (2022). Pielęgniarstwa, 30(4), 143-148. https://doi.org/10.5114/ppiel.2022.126824 Chicago Iwona, Katarzyna and Aleksandra Szarek. 2022. "Social students". Pie...

BACKGROUND Hepatocellular carcinoma (HCC) is regarded as one of the most common malignancies and among the leading causes of cancer death among the whole world. The most urgent needs are to find sensitive markers for early diagnosis or monitor postoperative recurrence and to give adequate treatment for HCC. MicroRNAs (miRNAs) are reported as a group of small non-coding RNAs that can function as...

BACKGROUND Although previous studies have shown promise for targeting Musashi RNA-binding protein 2 (MSI-2) in diverse tumors, the role and mechanism of MSI-2 for cervical cancer (CC) progression and the regulation of MSI-2 expression remains unclear. METHODS Using gene expression and bioinformatic analysis, together with gain- and loss-of-function assays, we identified MSI-2 as a novel oncog...

BACKGROUND Febrile seizures are common in young children. Annual peaks in incidence mirror increased respiratory virus activity during winter. Limited virological data are available using modern diagnostic techniques for children with febrile seizures. We aimed to determine the frequency of detection of specific viral pathogens in children with febrile seizures, to describe risk factors includi...

BACKGROUND Androgen levels in the prostate may influence carcinogenesis in this organ. Inhibitors of the enzyme 5alpha-reductase block conversion of testosterone to the more active androgen dihydrotestosterone. The use of a 5alpha-reductase inhibitor, finasteride, in the chemoprevention of prostate cancer is being evaluated in a clinical trial. PURPOSE This study was conducted to determine if...