Let S be a reduced commutative cancellative atomic monoid. If s is a nonzero element of S, then we explore problems related to the computation of η(s), which represents the number of distinct irreducible factorizations of s ∈ S. In particular, if S is a saturated submonoid of Nd , then we provide an algorithm for computing the positive integer r(s) for which 0 < lim n→∞ η(sn) nr(s)−1 <∞. We fur...

Hereditary hemochromatosis is most commonly caused by homozygosity for a point mutation (C282Y) in the human hemochromatosis gene (HFE). The mechanism by which HFE regulates iron absorption is not known, but the C282Y mutation results in loss of cell surface expression of the human hemachromatosis protein (HFE) and hyperabsorption of iron by the duodenal enterocyte. Mice homozygous for a deleti...

The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In Tand pre-B-cell lymphoma, KLF4 was found to act as tumor suppressor. We found the KLF4 promoter methylated in B-cell lymphoma cell lines and in primary cases of B-cell lymphomas, namely, follicular lymphoma, diffuse large B-cell lymphoma, Burkitt lymphoma, and in classic Hodgkin lym...

2. Strasek Smrdel K, Tozon N, Duh D, Petrovec M, Avsic Zupanc T. Diversity of groESL sequences of Anaplasma phagocytophilum among dogs in Slovenia. Clin Microbiol Infect. 2009;15(Suppl 2):79– 80. http://dx.doi.org/10.1111/j.1469-0691. 2008.02201.x 3. Masuzawa T, Uchishima Y, Fukui T, Okamoto Y, Muto M, Koizumi N, et al. Detection of Anaplasma phagocytophilum from wild boars and deer in Japan. J...

References 11–71 can be found in Supplementary data online. 1. Goldstein JA. Angiographic plaque complexity: the tip of the unstable plaque iceberg. J Am Coll Cardiol 2002;39:1464–7. 2. Moreno PR, Muller JE. Identification of high-risk atherosclerotic plaques: a survey of spectroscopic methods. Curr Opin Cardiol 2002;17:638–47. 3. Jaffer FA, Verjans JW. Molecular imaging of atherosclerosis: cli...

Birth weight has been associated with a subsequent risk of breast cancer. The present study examined associations between birth weight and pregnancy estrogens and Afetoprotein (AFP). The concentrations of estradiol, estriol, and AFP were measured in maternal and umbilical cord blood samples from 194 women during pregnancy and at birth. Birth weight was significantly positively correlated with m...

In the present study, the mechanism of double-strand-break (DSB) repair during gene targeting at the chromosomal immunoglobulin mu-locus in a murine hybridoma was examined. The gene-targeting assay utilized specially designed insertion vectors genetically marked in the region of homology to the chromosomal mu-locus by six diagnostic restriction enzyme site markers. The restriction enzyme marker...

We recently reported that forced overexpression of the transcription factor E2F-1 in human HT-1080 fibrosarcoma cells resulted in corresponding high levels of thymidylate synthase (TS) and resistance to 5-fluoropyrimidines (D. Banerjee et al., Cancer Res., 58: 4292–4296, 1998). Because colorectal metastasis to the lung has higher TS levels than liver metastasis and is less responsive to treatme...