A primary function of B lymphocytes is immunoglobulin production; however, the therapeutic benefit of B cell depletion in autoimmune diseases previously thought to be T cell mediated suggests that some B cells fulfill other roles in autoimmunity. We examined the recently identified human B1 cell population for T cell stimulatory activity. We found two kinds of B1 cells that are distinguished by...

هدفت هذه الدراسة إلى تتبع سير إدريس بن عبد الله في المشرق، وما الذي دفعه الاتجاه نحو المغرب الأقصى تحديداً، ثم الاستقرار مدينة وَلِيلي، نشوء الكيان السياسي المعروف بدولة الأدارسة. تقوم على المنهج العلمي يستندُ، الوصف والتحليل والنقد، فهو يستقرئ الروايات التاريخية ويُحلل مضامينها ويقارن بين كل المعطيات. قُسِّمَ البحث مقدمة وعدة عناوين وخاتمة، وتشتمل المقدمة موضوع وأهميته ومصادر الدراسة، محور مقسم إلى: ال...

BACKGROUND We have previously reported that glycerol acts as a chemical chaperone to restore the expression of WAF1 in some human cancer cell lines bearing mutant p53. Since the expression of WAF1 is up-regulated by activated wildtype p53, glycerol appears to restore wtp53 function. The aim of the present study is to examine the restoration of heat-induced p53-dependent apoptosis by glycerol in...

AMA Napłoszek K, Lewtak K. Oral health-related quality of life among young adults in Poland. Family Medicine & Primary Care Review. 2023;25(2):172-183. doi:10.5114/fmpcr.2023.127676. APA Napłoszek, K., Lewtak, (2023). Review, 25(2), 172-183. https://doi.org/10.5114/fmpcr.2023.127676 Chicago Kamila, and Katarzyna Lewtak. 2023. "Oral Poland". Review 25 (2): Harvard pp.172-183. MLA Kamila et al. P...

the aims of the present study was to evaluate the level of aflatoxin b1 (afb1) in feedstuffs (corn silage, corn, dried alfalfa, cottonseed meal, cottonseed, soybean meal, canola meal, barley, wheat bran, concentrate, sugar beet pulp and wheat straw) that collected from dairy herds in khorasan razavi province that classified according to milk yield in very high (>10000 kg/day), high (5000-10000 ...

Mitosis is triggered by the activation of Cdk1-cyclin B1 and its translocation from the cytoplasm to the nucleus. Positive feedback loops regulate the activation of Cdk1-cyclin B1 and help make the process irreversible and all-or-none in character. Here we examine whether an analogous process, spatial positive feedback, regulates Cdk1-cyclin B1 redistribution. We used chemical biology approache...

BACKGROUND Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. We tested the hypothesis that the expression of Plex-B1, either alone or in association with Met, can be of predictive value for tumour progressi...