نتایج جستجو برای: 2 3 7 8
تعداد نتایج: 3818168 فیلتر نتایج به سال:
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BACKGROUND There is evidence for a role of ionizing radiation in cardiovascular diseases. The goal of this work was to identify changes in oxidative and nitrative stress pathways and the status of the endothelinergic system during progression of atherosclerosis in ApoE-deficient mice after single and repeated exposure to ionizing radiation. METHODS AND RESULTS B6.129P2-ApoE tmlUnc mice on a l...
Abstract Coumarin and its nitrogen analogue 1-aza coumarin are a class of lactones lactams, respectively, which indispensable heterocyclic units to both chemists biochemists. 1-Aza derivatives, ultimately metabolize as the corresponding 8-hydroxy coumarins in biological system therefore found be very good anti-inflammatory, anti-cancer, analgesic agents. A series hybrid substituted azacoumarin-...
Anthracycline-based chemotherapy regimens are the cornerstone of first-line treatment recurrent/metastatic unresectable soft tissue sarcoma(STS). Anlotinib is a multi-targeted tyrosine kinase inhibitor with confirmed efficacy in STS. Penpulimab new type anti-PD-1 monoclonal antibody. We conducted this trial to explore safety and Penpulimab(P) plus anlotinib(A) epirubicin(E) Here we reported res...
The internal dye labeling of DNA by the Huisgen-Meldal-Sharpless "click" reaction is described. Fluorogenic 9-azidomethyl anthracene 2 and 3-azido-7-hydroxycoumarin 3 were employed in the postsynthetic functionalization of oligonucleotides incorporating octa-(1,7)-diynyl-8-aza-7-deaza-2'-deoxyadenosine 1. Nucleoside 1 was prepared by Sonogashira cross coupling from the corresponding 7-iodo comp...
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