Antibiotic production and resistance pathways in Streptomyces are dictated by the interplay of transcriptional regulatory proteins that trigger downstream responses via binding to small diffusible molecules. To decipher the mode of DNA binding and the associated allosteric mechanism in the sub-class of transcription factors that are induced by γ-butyrolactones, we present the crystal structure ...

Synthesis of poly(vinyl chloride-g-β-butyrolactone) [poly(VC-g-BL)] graft copolymer was carried out by means “click” chemistry terminally propargyl polyβ-butyrolactone ester (PBL-propargyl) and polyvinyl chloride with pendant azido group (PVC-N3). PVC-N3 synthesized reaction purified PVC sodium azide. PBL-propargyl obtained the β-butyrolactone alcohol ring-opening polymerization. By using PBL-p...

The addition products of Ti(IV)-enolate derived from b-keto a-diazo carbonyl compound to ketones or a,b-unsaturated compounds were subjected to Rh2(OAc)4-catalyzed and photo-induced diazo decomposition. The Rh2(OAc)4-catalyzed reaction afforded intramolecular O–H insertion products, while the photo-induced reaction gave Wolff rearrangement/intramolecular nucleophilic addition products. The tran...

The thermal degradation behavior of poly[(R)-3-hydroxybutyrate-co-16 mol%-4-hydroxybutyrate] (P(3HB-co-16 mol%-4HB)) was investigated based on spectroscopic analysis its pyrolyzates and two kinetic modeling approaches. Pyrolyzate revealed that trans-crotonic acid, cis-crotonic γ-butyrolactone, their oligomers (dimers trimers) were produced following P(3HB-co-16 mol%-4HB). analyses confirmed the...

Many streptomycetes produce extracellular gamma-butyrolactones. In several cases, these have been shown to act as signals for the onset of antibiotic production. Synthesis of these molecules appears to require a member of the AfsA family of proteins (AfsA is required for A-factor synthesis of the gamma-butyrolactone A-factor and consequently for streptomycin production in Streptomyces griseus)....

As a follow-up to our effort establish reliable thermodynamic data for amino acids, the heat capacity and phase behavior are reported N-acetyl glycine amide (CAS RN: 2620-63-5), N-acetyl-L-alanine 15962-47-7), N-acetyl-L-valine 37933-88-3), N-acetyl-L-isoleucine 56711-06-9), N-acetyl-L-leucine 28529-34-2). Prior measurement, thermogravimetric analysis X-ray powder diffraction were performed det...