In the present investigation surface modification of silica nanoparticles by alumina was carried out by sol-gel process. Fourier transform infrared (FTIR) and X-ray fluorescence (XRF) confirmed the synthesis of silica and the surface modification as alumina is anchored to silica surface. Field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) investigation...

Whereas the cytostatic properties of the antibiotic streptonigrin (1) and its amides and esters have been studied1~4), structure-activity relationships for other derivatives of 1, as well as for derivatives of antibiotic streptonigrone (2), which is a minor component of the streptonigrin complex5), remain to be investigated. In this paper we describe the synthesis of 2/-decarboxy-2/-aminostrept...

Transgenic animals offer many advantages for physiological study. The mouse is the most extensively utilized mammalian model for gene modification. Isolated ventricular myocytes are pivotal for assessment of cardiac function by allowing direct cellular and environmental manipulation without interference from compensatory mechanisms that may exist in vivo. This study was designed to compare the ...

This article is a report on a novel and high-stability biosensor with minor interference effects of surface modification of working electrode with β-Ga2O3 nanowires (NWs) on choline oxidase biosensor were investigated in an electrochemical detection system. β-Ga2O3 NWs were materialized on the silicon substrate in a catalyst-free growth mechanism. The β-Ga2O<sub...

Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two distinct histone modification complexes. A 5' domain of HOTAIR binds polycomb repressive complex 2 (PRC2), whereas a 3' domain of HOTAIR binds the LSD1/CoREST/REST complex. The ability to tether two distinct complexes enables...

Many DNA modification and repair enzymes require access to DNA bases and therefore flip nucleotides. Restriction endonucleases (REases) hydrolyze the phosphodiester backbone within or in the vicinity of the target recognition site and do not require base extrusion for the sequence readout and catalysis. Therefore, the observation of extrahelical nucleotides in a co-crystal of REase Ecl18kI with...