We recently reported that a novel hetero-oligomeric P2X receptor is formed from the P2X(1) and P2X(5) isoforms when coexpressed in human embryonic kidney 293 cells (). A more complete description of the pharmacology of this novel receptor is presented here. A brief application of ATP to a voltage-clamped cell transiently expressing P2X(1/5) receptors resulted in a biphasic current that rapidly ...

We have previously reported the anti-neoplastic properties of ~-methylthio-4-amino-5-hydroxymethylpyrimidine (methioprim) and of other related pyrimidines with modification of the 2alkylthio substituent (2). These compounds were initially chosen for study following the observations of Guthrie et a/. that collateral sensitivity for methioprim was demonstrable in amethopterin-resistant strains of...

1-Benzyl-2-(methylthio)-imidazole-5-ketone is obtained in a few simple steps starting from thiocyanate and glycine amide (glycin). Subsequent treatment with diethyl phosphorocyanidate and functional group manipulations gives 1-benzyl-5-chloromethyl-imidazolium chloride. This compound is converted under mild O'Donnell conditions into the corresponding L-histidine derivative. After deprotection L...

The 1:1 and 1:2 phases (TTM -TTF)Br, and (TTM -TTF)(Br3)2, TTM-TTF = tetra(methylthio)tetrathiafulvalene, C UIH 12S8, have been crystallized by diffusion of bromine vapour into solutions of the donor. The 1:1 salt is monoclinic, P 2xln, a = 7 .587(2), b = 11.424(3), c = 23.145(8) Ä , ß = 95.80(3)°, V = 1997 Ä 3, Z = 4, Mr = 628.45, dc = 2.09 g e m '3, final Rw = 0.028 for 912 reflections. The 1...

Alkyl 2-cyano-3-methylthio-3-phosphonylacrylates were synthesized by the reaction of alkyl 2-cyano-3,3-dimethylthioacrylates with dialkyl phosphites. The structures of the new compounds were characterized by elemental analyses, IR, 1H-, 13C- and 31P-NMR spectral data. These compounds were tested in vitro against pathogenic fungi, namely, Fusarium graminearum, Cytospora mandshurica and Fusarium ...

Thirty-seven basidiomycetous yeasts belonging to 30 species of seven genera were grown on media containing l-cysteine or l-methionine as sole nitrogen sources with the objective of evaluating volatile organic sulfur compound (VOSC) production. The headspace of yeast cultures was analyzed by the solid-phase microextraction (SPME) sampling method, and volatile compounds were quantified and identi...