In the title compound, C(19)H(23)IN(2)O(2), the cyclo-hexane ring adopts a chair conformation, and the mean plane of the propiolamide unit is approximately perpendicular to the benzene ring [dihedral angle = 88.12 (13)°]. Weak intra-molecular C-H⋯O hydrogen bonding is observed between the carbonyl group and the benzene ring. In the crystal, classical N-H⋯O hydrogen bonds and weak C-H⋯O inter-ac...

Binding of the hepatocarcinogen 2-acetylaminofluorene (AAF) and two metabolites, 2-aminofluorene (AF) and N-hydroxy-2-acetylaminofluorene (N-OH-AAF), to the DNA and protein of rat hepatic nuclei was examined in vitro and in a cell-free system. Three and one-half hr following a single injection of each compound in equimolar amounts. DNA contained approximately 50% more of the compounds per mg th...

n, n΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of n, n΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚c. under similar conditions n, n΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and n, n΄-3, 4-di(isopropylamino)-1, 2, 5-oxadiazole (1e) were not obtained, but, n, n΄-3, 4-di(ethylamino)-1, 2, 5-oxadiazole (1g) was appeared with smal...