Increased aortic stiffness is a biomarker for subsequent adverse cardiovascular events. We have previously reported that vascular smooth muscle Src-dependent cytoskeletal remodelling, which contributes to aortic plasticity, is impaired with ageing. Here, we use a multi-scale approach to determine the molecular mechanisms behind defective Src-dependent signalling in an aged C57BL/6 male mouse mo...

UNLABELLED We developed a radioligand, 3-fluoro-5-(2-(2-(18)F-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile ((18)F-SP203), for metabotropic glutamate subtype 5 (mGluR5) receptors that showed both promising (high specific binding) and problematic (defluorination) imaging characteristics in animals. The purposes of this initial evaluation in human subjects were to determine whether (18)F-SP203 ...

يعد النشاط الاقتصادي عصب الحياة وأساس قيام الدول واستمرارها، فهو الموجه الرئيسي لها، ومن خلاله تقاس مكانتها ، ونظرا للدور المهم الذي لعبه هذا الجانب في نشأة وتطور موانئ المغرب الأوسط، جاءت هذه الدراسة الموسومة أثر العلاقات التجارية ازدهار لموانئ الأوسط خلال المدة (ق 5-7هـ/11-13م)، والتي تتضمن مبحثين تناول المبحث الأول منها مع بلدان العالم الاسلامي، إضافة الى الحديث عن أهم السلع والبضائع المتباد...

BACKGROUND It has been reported that miR-203 expression was aberrant in various types of cancers, and it could be used as a prognostic biomarker. Therefore, in this study, we aimed to evaluate the prognostic value of miR-203 expression in solid tumors by using meta-analysis and The Cancer Genome Atlas (TCGA) datasets. METHODS By doing a literature research in PubMed, Embase and the Cochrane L...

OBJECTIVE Estradiol (E2) regulates gene transcription by activating estrogen receptor-α and estrogen receptor-β. Many of the genes regulated by E2 via estrogen receptors are repressed, yet the molecular mechanisms that mediate E2-induced gene repression are currently unknown. We hypothesized that E2, acting through estrogen receptors, regulates expression of microRNAs (miRs) leading to repressi...

Penelitian ini memfokuskan pada kemampuan Masayarakat Banyumas dalam mengucapkan huruf-huruf Bahasa Arab ketika mereka belajar alquran. Jenis penelitian yang digunakan adalah deskriptif kualitatif dengan model studi kasus. Objek dikaji huruf sedangkan subjek terdiri dari jamaah pengajian dan pengajar alquran di masjid tempat penelitian. Teknik pengumpulan data wawancara, observasi, dokumentasi....

Current treatments for patients with Crohn's disease (CD) are based on recent advances in elucidating the pathophysiology of the disease. A satisfactory therapeutic strategy has not been well established. A new sphingosine 1-phosphate (S1P) receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), has been developed for immunomodulation in autoimmune diseases and organ transplantation. W...

Long non-coding RNAs (lncRNAs) have been reported to be of great importance in the formation and progression of a wide range of human carcinomas including prostate cancer (PCa). Among them, PCAT3 and PCAT9 have been identified as two prostate tissue-specific lncRNAs and are up-regulated in PCa. However, their roles in the biological characteristics of PCa have not been fully elucidated. In the ...

Galectin-7, a member of the β-galactoside-binding protein family, is primarily expressed in stratified epithelial cells, including keratinocytes. There is information in the literature suggesting a role for this protein in regulation of keratinocyte survival and growth, but the underlying mechanism remains relatively unknown. Moreover, its expression pattern in the epidermis suggests that it is...

MicroRNAs (miRNAs) are a family of small, non-coding RNAs (17-24 nucleotides), which regulate gene expression either by the degradation of the target mRNAs or inhibiting the translation of genes. Recent studies have indicated that miRNA plays an important role in regulating osteoblast differentiation. In this study, we identified miR-203 and miR-320b as important miRNAs modulating osteoblast di...