Invasive pneumococcal disease (IPD) is caused Surveillance System (NNDSS). The data in this by the bacterium Streptococcus pneumoniae and report are provisional and subject to change as results in illnesses such as pneumonia, bactelaboratory results and additional case informaraemia and meningitis. There are currently 92 tion become available. The data are analysed serotypes recognised worldwid...

The number of notified cases of invasive pneumococcal disease (IPD) in the 4th quarter of 2016 (n = 389) was less than the previous quarter (n = 643), but more than the number of notified cases in the 4th quarter of 2015 (n = 314). Overall, the decline in disease due to the serotypes targeted by the 13-valent pneumococcal conjugate vaccine (13vPCV) has been maintained across all age groups, sin...

Serotyping data for pneumococci causing invasive and noninvasive disease in 2008-2009 and 2010-2011 from >43 US centers were compared with data from preconjugate vaccine (1999-2000) and postconjugate vaccine (2004-2005) periods. Prevalence of 7-valent pneumococcal conjugate vaccine serotypes decreased from 64% of invasive and 50% of noninvasive isolates in 1999-2000 to 3.8% and 4.2%, respective...

Several epidemiological studies have evidenced that children with underlying chronic conditions are at increased risk of pneumococcal infections with higher case-fatality rates than healthy subjects. Because pharyngeal pneumococcal carriage is a prerequisite for pneumococcal infection development, the high colonization rates found in these subjects is the most important reason for this phenomen...

The suboptimal efficacy of the currently available 23-valent pneumococcal vaccine in the growing population of adults >65 years old may be related to the limited immunogenicity of the vaccine polysaccharides in this group. In this study, the majority of elderly outpatients with stable chronic illnesses generated a vigorous IgG response to seven vaccine serotypes comparable to that of healthy yo...

Invasive pneumococcal diseases are the main cause of morbidity and mortality in children. In the Hospital "Prof. Dr. Juan P. Garrahan", between October 1st , 2008 and September 30th, 2011 all invasive pneumococcal diseases with positive blood cultures were retrospectively studied before the implementation of the universal immunization schedule with the 13-valent pneumococcal conjugate vaccine. ...

Streptococcus pneumoniae is a leading cause of pneumonia, the most common cause of childhood death. Papua New Guinean children experience high rates of nasopharyngeal pneumococcal colonization within weeks of birth, predisposing them to pneumococcal disease. In a trial to determine the safety and immunogenicity of early infant vaccination with 7-valent pneumococcal conjugate vaccine (7vPCV), we...

Invasive pneumococcal disease is a significant cause of morbidity and mortality worldwide. The aim of this study was to establish the serotypes responsible for pneumococcal disease and the serotypes responsible for penicillin resistance in Noumea, New Caledonia. Isolates of Streptococcus pneumoniae from all body sites referred to the Microbiology Department of the Pasteur Institute in New Caled...

BACKGROUND Newly diagnosed HIV-positive individuals are 35 to 100-fold more susceptible to Streptococcus pneumoniae infection compared to non-infected individuals. Therefore, the 23-valent pneumococcal polysaccharide vaccine (PPV23) has previously been recommended, though efficacy and effectiveness of vaccination remains controversial. Early severe B cell dysfunction is a central feature of HIV...

Streptococcus pneumoniae is a major cause of morbidity and mortality in infants, children and the elderly. Despite the availability of excellent antimicrobial therapy and adequate health care systems, respiratory diseases and invasive infections caused by pneumococci still comprise a major health problem. The emerging resistance to penicillin and other commonly used antibiotics underscores the ...