Georgios P. SPITHOURAKIS*, Fotios PETROPOULOS Forecasting & Strategy Unit, School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece Konstantinos NIKOLOPOULOS Bangor Business School, Bangor University, Bangor LL57 2DG, UK & Vassilios ASSIMAKOPOULOS Forecasting & Strategy Unit, School of Electrical and Computer Engineering, National Technical Universi...

BACKGROUND Glioblastoma Multiforme (GBM) or grade IV astrocytoma is the most common and lethal adult malignant brain tumor. Several of the molecular alterations detected in gliomas may have diagnostic and/or prognostic implications. Proteomics has been widely applied in various areas of science, ranging from the deciphering of molecular pathogen nests of discuses. METHODS In this study protei...

The secretion of glucocorticoids in mammals is under circadian control, but glucocorticoids themselves are also implicated in modulating circadian clock gene expression. We have shown that the expression of the circadian clock protein PER1 in the forebrain is modulated by stress, and that this effect is associated with changes in plasma corticosterone levels, suggesting a possible role for gluc...

We have shown previously, acute intraperitoneal administration of 2-deoxy-d-glucose (2DG) into Sprague-Dawley rats led to activation the adrenal medulla chromaffin cells, indicated with increased protein kinase activity and tyrosine hydroxylase (TH) phosphorylation, as well plasma adrenaline glucose levels. Here we used spontaneous hypertensive (SHR) Wistar Kyoto (WKY) investigate whether hyper...

The growth of Streptococcus mutants Ingbritt in continuous culture at low pH or high growth rates repressed the biosynthesis of the components of the phosphoenolpyruvate:sugar phosphotransferase system (PTS). The cellular concentrations of the soluble components HPr, enzyme I (EI), and EIII for mannose (IIIman) and EII activity for glucose, mannose, 2-deoxyglucose (2DG), and fructose were deter...

Purpose:Cancer cells (relative to normal cells) show increased steady-state levels of hydroperoxides that are compensated by increased glucose and hydroperoxide metabolism. The current study determined whether inhibitors of glucose and hydroperoxide metabolism could induce chemoradiosensitization by enhancing oxidative stress in lung cancer cells. Experimental Design: A549 and NCI-H292 human lu...