In the title compound, C(20)H(18)N(2) (2+)·2Br(-)·2H(2)O, the complete dication is generated by a crystallographic centre of symmetry. In the crystal, O-H⋯Br, C-H⋯Br and C-H⋯O hydrogen bonds and π-π stacking [shortest centroid-centroid separation = 3.657 (2) Å] help to establish the packing.

OBJECTIVE To assess the efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection (URTI). MATERIALS AND METHODS This multicenter, double-blind, double-dummy, non-inferiority study randomized 440 adults with recent-onset, moderate-to-severe sore throat due to URTI to a single dose of either flurbiprofen 8.75 mg spray ...

(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid methyl ester(1) upon reaction with ethyl bromoacetate furnishes (7-ethoxycarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid methylester (2), which on treatment with 100% hydrazine hydrate yields (7-hydrazinocarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (3). The condensation of compound 3 with different aromatic aldehydes afforded a se...

Herein the synthesis of a new ethynyl ferrocenyl amidinate ligand [Fc?C?C-{C(Ndipp)$_{2}$H}] (Fc=ferrocenyl; dipp=diisopropylphenyl) and subsequent formation corresponding samarium amido complex [Sm{Fc?C?C-[C(Ndipp)$_{2}$$_{2}$]}$_{2}${N(SiMe$_{3}$3)$_{2}$}] is reported. [Fc?C?C-{C(Ndipp)2H}] [Sm{Fc?C?C-[C(Ndipp)$_{2}$]}$_{2}${N(SiMe$_{3}$)$_{2}$}] were fully characterized including study compl...

AIMS To investigate efficacy and safety of the sodium-glucose co-transporter 2 (SGLT2) inhibitor canagliflozin administered as add-on therapy to the dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS We conducted a multicentre, randomized, double-blind, placebo-controlled, phase 3 clinical trial in Japanese patients w...

The title compound, C(9)H(14)N(2)O, exists in the zwitterionic form in the crystal. The cyclo-octane ring adopts a twisted boat-chair conformation. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into sheets lying parallel to bc. The structure is also stabilized by π-π inter-actions, with a centroid-to-centroid distance of 3.5684 (8) Å.

Parvibaculum lavamentivorans DS-1(T) utilized the commercial surfactant linear alkylbenzenesulfonate (LAS) (20 congeners with C(10) to C(13) side chains) as a carbon and energy source by shortening the side chain, and sulfophenylcarboxylates (SPCs) and similar compounds (e.g., alpha,beta-unsaturated SPCs [SPC-2Hs]) were excreted with quantitative recovery of the sulfophenyl moiety. 2-(4-Sulfoph...

In the crystal structure of the title compound, C(8)H(20)N(+)·C(4)H(5)O(6) (-)·2H(2)O, the ions and water mol-ecules are linked via O-H⋯O and C-H⋯O hydrogen bonds, forming a two-dimensional network parallel to (001).

The title compound 6-amino-3-benzylmercapto-1,2,4-triazolo[3,4-f][1,2,4]-triazin-8(7H)-one (4), molecular formula C(11)H(10)N(6)OS, was obtained by the reaction of 3-amino-2-benzyl-6-hydrazino-1,2,4-triazin-5(2H)-one (3) with carbon disulfide in a water/pyridine mixture. Compound 4 can also be synthesized by reacting 6-amino-3(2H)mercapto-1,2,4-triazolo[3,4-f][1,2,4]triazin-8(7H)-one (7) with b...