The effects of the use of Paritol administered intravenously to 35 individuals are herein reported. This synthetic anticoagulant produces a prolongation of the clotting time similar to that produced by heparin but of longer duration, if appropriate dosage is used. As with heparin, at therapeutic clotting time levels, the prothrombin time is slightly prolonged. Certain untoward effects have been...

The topic of this thesis is the simulation of blood clotting using the Lattice Boltzmann method and taking into account the non-Newtonian behavior of blood. This kind of simulations could be used for the treatment of diseases like stenosis and aneurysms. Their field of application includes the diagnostic of the diseases, the planning of surgeries and the investigation of new medical treatment s...

Realistic description of patient-specific mechanical properties of clotting dynamics presents a major challenge. Available patient-specific data falls short of robustly characterizing myriads of complex dynamic interactions that happen during clotting. We propose a simplified switching model for a key part of the coagulation cascade that describes dynamics of just four variables. The model corr...

A major variable in blood coagulation tests is the nature and the amount of surface with which the blood comes in contact. When tests on recalcified plasma are used the methods of preparation and storage of the plasma have also to be considered. The prolonged contact of plasma with a large surface, e.g., with glass powder or asbestos, is accompanied by the loss of many coagulation factors, incl...

IN TESTS OF PLATELET FUNCTION IN NORMAL SUBJECTS, THE FOLLOWING RELATIONSHIPS WERE FOUND: the greater the platelet adhesiveness the less the ability to disaggregate after challenge with adenosine diphosphate (ADP), and the greater the disaggregation after ADP, the longer the clotting time in the test for platelet factor 3 availability. Such correlations were disturbed in uraemic patients.

Thromb Haemost 2007; 98: 20–23 To browse through old work is a pleasure in the indian summer of a career, not devoid of nostalgia.As the large majority of our early work appeared inThrombosis and Diathesis Haemorrhagica, the present issue is an appropriate occasion to do so and to review old results, holding them against the light of our present day knowledge – and apologising beforehand for th...

I T HAS been demonstrated, qualitatively, that the rate of blood coagulation is related to the presence of blood platelets. This relationship has been known to exist in bird blood since the investigations of Delezenne (I). In mammalian blood, however, conflicting data and opinions regarding the role of platelets in coagulation have been published during the past half-century. Only in the past d...

The results of our study may briefly be summarized as follows: 1) The irradiation with microrays (20∼30 watts) similar as 2,000 R and 5,000 R Gamma radiation did not substantially affect the activity of fibrinolysin (SK+SD). 2) By the irradiation method so far mentioned it has been demonstrated that the fibrinolytic activity of anticoagulant of the SK+SD preparation is preserved in all the clot...

Polylysine has been shown to possess various biological activities. It is bacteriostatic (Katchalski, Bichowski-Slomnitzki & Volcani, 1953) and virostatic (Stahmann, Graf, Patterson, Walker & Watson, 1951); it inhibits thromboplastic activity (de Vries et al. 1951), fibrinolysis (Ginsburg, de Vries & Katchalski, 1952), the proteolytic activity of pepsin (Katchalski, Berger & Neumann, 1954) and ...