The purpose of this study was to investigate the oxidative damage induced by dietary nickel chloride (NiCl2) in the intestinal mucosa of different parts of the intestine of broilers, including duodenum, jejunum and ileum. A total of 240 one-day-old broilers were divided into four groups and fed on a corn-soybean basal diet as control diet or the same basal diet supplemented with 300, 600 or 900...

The objective of this study was to determine the effects of two different time of GnRH injection after artificial insemination (A.I) (d 6 and d 12) on reproductive performances of Holstein cows during the warm season.  Cows randomly assigned to treatments 1) No GnRH injection (control, n = 300),2) GnRH injection at day 6 after A.I (G6, n=300) and 3) GnRH injection at day 12 after A.I (G12, n=30...

INTRODUCTION: Strenuous exercise in sedentary individuals increases the acute risk of atherothrombotic events and depletes endogenous antioxidants. Supplementation with the antioxidant tocopherol ameliorates the risk; however it is unclear whether α-tocopherol, γ-tocopherol or a combination of both is more efficacious. We therefore measured the effects of γ-,αand mixed tocopherol supplementatio...

The immunosuppressive effect of rapamycin is mediated by inhibition of interleukin-2-stimulated T cell proliferation. We report for the first time that rapamycin also inhibits growth factor-induced proliferation of cultured mouse proximal tubular (MPT; IC(50) ~1 ng/ml) cells and promotes apoptosis of these cells by impairing the survival effects of the same growth factors. On the basis of these...

INTRODUCTION: Strenuous exercise in sedentary individuals increases the acute risk of atherothrombotic events and depletes endogenous antioxidants. Supplementation with the antioxidant tocopherol ameliorates the risk; however it is unclear whether α-tocopherol, γ-tocopherol or a combination of both is more efficacious. We therefore measured the effects of γ-,αand mixed tocopherol supplementatio...

1. This placebo-controlled study assessed once daily sustained-release (SR) diltiazem, 200 and 300 mg, in 182 stable angina patients with positive exercise test. 2. Exercise testing was performed at baseline after a 7 day placebo run-in period, and repeated after 7 days of treatment, 25.0 +/- 0.1 h postdose. 3. Diltiazem (200 and 300 mg) produced respectively a 68% and a 64% decrease in weekly ...

BACKGROUND Indacaterol is a novel once-daily ultra long-acting β2-agonist for the treatment of chronic obstructive pulmonary disease. It is known that β2-agonists, like other adrenergic compounds, can prolong the QT-interval. This thorough QT/QTc study (as per ICH E14 guideline) evaluated the effect of indacaterol on the QT interval in healthy subjects. METHODS In this randomized, double-blin...

BACKGROUND This randomised, double-blind, placebo controlled, four-period crossover study assessed the efficacy and safety of once-daily QVA149, a dual bronchodilator consisting of the long-acting β2-agonist indacaterol and the long-acting muscarinic antagonist glycopyrronium (NVA237), in patients with moderate to severe chronic obstructive pulmonary disease (COPD). METHODS Patients (N=154) w...

PURPOSE To evaluate the safety, pharmacokinetics, and biological activity of suberoylanilide hydroxamic acid (SAHA) administered by 2-h i.v. infusion in patients with advanced cancer. EXPERIMENTAL DESIGN SAHA was administered for 3 days every 21 days in part A and 5 days for 1-3 weeks in part B. Dose escalation proceeded independently in patients with solid tumor and hematological malignancie...