نتایج جستجو برای: 315
تعداد نتایج: 6306 فیلتر نتایج به سال:
Cultured spleen cells from normal or MOPC-315 tumor-bearing BALB/c mice that were pretreated in vivo with Bacillus Calmette-Guérin (BCG) exhibited in vitro cytotoxicity against MOPC-315 plasmacytoma. In vitro education of BALB/c spleen cells from normal or tumor-bearing mice by cocultivation with mitomycin C-treated MOPC-315 stimulator cells also resulted in antitumor cytotoxicity. The combinat...
Humanized monoclonal antibody KD-247 targets the Gly(312)-Pro(313)-Gly(314)-Arg(315) arch of the third hypervariable (V3) loop of the HIV-1 surface glycoprotein. It potently neutralizes many HIV-1 clade B isolates, but not of other clades. To understand the molecular basis of this specificity, we solved a high-resolution (1.55 Å) crystal structure of the KD-247 antigen binding fragment and exam...
The existence of vast regulatory networks mediated by microRNAs (miRNAs) suggests broad potential for miRNA dysfunction to contribute to disease. However, relatively few miRNA-target interactions are likely to make detectable contributions to phenotype, and effective strategies to identify these few interactions are currently wanting. We hypothesized that signaling cascades represent critical p...
Uncultured tumor-infiltrated spleen cells (TISpC) from mice bearing large (20-22 mm) s.c. MOPC-315 plasmacytomas were previously shown to be ineffective in bringing about the cure of mice bearing a nonpalpable (Day 4) tumor that had been treated with a subcurative dose (10 mg/kg) of cyclophosphamide (i.e., adoptive chemoimmunotherapy, ACIT) (M. B. Mokyr, J. C. D. Hengst, and S. Dray, Cancer Res...
BACKGROUND Multiple myeloma (MM) is a B-cell malignancy, where malignant plasma cells clonally expand in the bone marrow of older people, causing significant morbidity and mortality. Typical clinical symptoms include increased serum calcium levels, renal insufficiency, anemia, and bone lesions. With standard therapies, MM remains incurable; therefore, the development of new drugs or immune cell...
سلامت روانی والدین دانش آموزان دارای اختلال نارسایی توجه/ فزون ـ کنشی (adhd) با والدین دانش آموزان بهنجار مقایسه شد. معلمان 315 دختر و 315 پسر 7 تا 11 ساله فهرست نشانه مرضی کودک csi-4 (گدو و اسپرافکین، 1994) را تکمیل کردند. دو گروه (در هر گروه 15 دختر و 23 پسر) از دانش آموزان واجد اختلال و فاقد اختلال adhd انتخاب شدند. سپس والدین تمام 76 دانش آموز به پرسشنامه سلامت عمومی (گلدبرگ، 1972) پاسخ داد...
Pur~osg: Nsovascular glaucoma is a severe complication of diabetic retinopathy but its natural evolution is not sufficiently known. In this paper we study the trabecular meshwork of patients who have been operated because of nsovascular glaucoma with the aim to stablish the distribution of neovessels and to understand the mechanism of formation of goniosinechiae and the possible obstruction of ...
Noncytotoxic spleen cells from BALB/c mice bearing 15- to 26-mm (but not 29-mm) s.c. MOPC-315 tumors that were cultured in medium containing 2% polyethylene glycol 6000 (PEG) developed substantial levels of anti-MOPC-315 cytotoxicity as assayed by 51Cr release. The level of cytotoxicity obtained increased with progression of tumor growth. Addition of mitomycin C-treated stimulator tumor cells a...
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