Aberrant activation of EGFR is seen in many solid cancers, which has led to the development EGFR-targeted anti-cancer therapies. However, epidermal growth factor receptor (EGFR) plays an important role hair morphogenesis and maintenance skin homeostasis. Therefore, cancer patients receiving inhibitors commonly develop a papulopustular rash, pruritus dry skin. Severe adverse events may require i...

The poliovirus RNA-dependent RNA polymerase, 3Dpol, is known to share a region of sequence homology with all RNA polymerases centered at the GDD amino acid motif. The two aspartic acids have been postulated to be involved in the catalytic activity and metal ion coordination of the enzyme. To test this hypothesis, we have utilized oligonucleotide site-directed mutagenesis to generate defined mut...

in the present study the effects of both cck receptor agonists and antagonists on antinociception induced by morphine in the tail-flick test have been evaluated. m orphine induced dose-dependent antinociception in mice. the response of morphine was potentiated by sulfated cholecystokinin-8 (cck-8s) but not by unsulfated cholecystokinin-8 (cck-8u). the cck receptor antagonists mk-329 and l-365, ...