Objective—Bile acids (BA) are elevated after vertical sleeve gastrectomy (VSG) and farnesoidX-receptor (FXR) is critical to the success of murine VSG. BA down-regulate hepatic lipogenesis by activating the FXR-small heterodimer partner (SHP) pathway. We tested the role of SHP in fatty liver disease (NAFLD) improvement after VSG. Design and Methods—Wild type (WT), SHP liver-transgenic (SHP-Tg) a...

TIME AND DATE: The Board of Directors of the Legal Services Corporation will meet on November 27, 2007 via conference call. The meeting will begin at 2 p.m., and continue until conclusion of the Board’s agenda. LOCATION: 3333 K Street, NW., Washington, DC 20007, 3rd Floor Conference Center. STATUS OF MEETING: Open, except that a portion of the meeting of the Board of Directors may be closed to ...

MHC genes in the chicken are arranged into two genetically independent clusters located on the same chromosome. These are the classical B system and restriction fragment pattern-Y (Rfp-Y), a second cluster of MHC genes identified recently through DNA hybridization. Because small numbers of MHC class I and class II genes are present in both B and Rfp-Y, the two clusters might be the result of du...

Dr Stanski conceptualized the topic, drafted the initial manuscript, and reviewed and revised the manuscript; Dr Patel conceptualized the topic and critically reviewed and revised the manuscript; and both authors approved the fi nal manuscript as submitted. DOI: 10.1542/peds.2015-3679 Accepted for publication Oct 2, 2015 Address correspondence to Natalja Stanski, MD, Department of Pediatrics, C...

OBJECTIVE To determine the healthcare utilization and medical care costs of women with a history of intimate partner violence (IPV) compared to women without a history of IPV. DESIGN Longitudinal cohort study. SETTING Mixed-model health maintenance organization. PARTICIPANTS Over 3000 (3333) women aged 18 to 64 years with > or = 3 year's cumulative enrollment prior to the survey, at least...

Low birth weight predicts adult essential hypertension and is linked to increased cardiovascular mortality in adult life. A reduction in capillary density (ie, rarefaction) is a hallmark of essential hypertension, and evidence suggests that rarefaction precedes the onset of the rise in blood pressure, because it is found in normotensive individuals at high risk of developing hypertension, sugge...

BACKGROUND This retrospective cohort study compared the risks of exacerbations and COPD-related healthcare costs between patients with chronic obstructive pulmonary disease (COPD) initiating tiotropium (TIO) alone and patients initiating triple therapy with fluticasone-salmeterol combination (FSC) added to TIO. METHODS Managed-care enrollees who had an index event of ≥ 1 pharmacy claim for TI...

Software in real-time embedded systems differs fundamentally from its desktop or Internet counterparts. Embedded computing is not simply computation on small devices. In most control applications, for example, embedded software engages the physical world. It reacts to physical and user-interaction events, performs computation on limited and competing resources, and produces results that further...