background: the effects of aqueous extract of fadogia agrestis stem at the doses of 18, 36, and 72 mg/kg body weight on alloxan-induced toxicity was investigated in wistar rats. methods: in total, 35 rats of both sexes (132.80±7.22g) were randomized into five groups (a-e): animals in group a received 0.5 ml of distilled water orally on daily basis for 15 days while the alloxanized rats in group...

Objective(s): Varenicline is a selective partial agonist for the nicotinic acetylcholine receptor a4b2 subtype, which is widely used to treat smoking addiction. However, there is still no data about its potential toxic effects on tissues. In this study, we aimed to determine the varenicline-induced toxicity on reproductive and renal tissues in rats.Ma...

BACKGROUND: The causal relationship between mutagenesis and carcinogenesis is well known. Hence the wide interest in study of mutagen-modifying effects natural synthetic compounds. Particular attention drawn to widespread One them, metformin, widely used as a hypoglycemic drug.
 AIM: evaluation influence metformin on cytogenetic doxorubicin cyclophosphamide mouse bone marrow cells.
 M...

BACKGROUND We investigated an outbreak involving 2 patients hospitalized at hospital A with cutaneous Rhizopus arrhizus (oryzae) infections of surgically created stomas. METHODS A cohort study involving all patients having ileostomy or colostomy surgery during the outbreak period (January-April 2005) was performed. Environmental samples, including samples obtained from nonsterile karaya (a pl...

objective(s): we aimed to examine association of gene expression of mor1 and glun1 at mrna level in the lumbosacral cord and midbrain with morphine tolerance in male wistar rats. materials and methods: analgesic effects of morphine administrated intraperitoneally at doses of 0.1, 1, 5 and 10 mg/kg were examined using a hot plate test in rats with and without a history of 15 days morphine (10 mg...

Methotrexatae (MTX) is a folate antagonist. MTX osteopathy is well recognized to accompany a high-dose therapy with this drug for the treatment of childhood malignancy. Clinical tests also show that low-dose MTX used in the treatment of rheumatoid arthritis may impair bone formation in a population already predisposed to osteoporosis. However, results of clinical tests are hard to interpret, as...

The risk-benefit balance of the full dose intravenous immunoglobulin (IVIG) infusion of 2 g/kg body weight/dose in older children has not been established. In this study, I investigated the safety and efficacy of this therapy for older children. In total, I recruited 210 children who had received 2 g/kg/dose of IVIG therapy for Kawasaki disease between 1999 and 2015 at the Department of Pediatr...

Objective(s): The wide scale use of Zinc oxide nanoparticles (ZnO NPs) in the consumer market world makes human beings more prone to the exposure to ZnO nanoparticles and its adverse effects. Therefore, the aim of the present study is to assess renal toxicity potential of ZnO and Polyethylene glycol Coated ZnO Nanoparticles in rat.Materials and Methods: Co-precipitation chemical method was used...