the reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1) with thionyl chloride afforded the corresponding acyl chloride 2. the reaction of compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)- thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole- 2-y1)-2,4-dihydro-3h- l,2,4-triazole-3- thione 4. alkylation an...

In the title compound, C(19)H(20)N(2)O, the dihedral angles between the 1,3,4-oxadiazole ring and the pendant 4-tert-butyl-phenyl and 4-methyl-phenyl rings are 12.53 (17) and 2.14 (17)°, respectively. In the crystal, mol-ecules are linked by C-H⋯N hydrogen bonds, forming chains.

The title mol-ecule, C(18)H(19)N(3)O(3), lies on a mirror plane that bis-ects the adamantyl group. In the crystal, C-H⋯O and C-H⋯N inter-actions lead to supra-molecular chains along [100]. These assemble into layers in the ab plane via π-π inter-actions [centroid-centroid distance = 3.6548 (7) Å] between the oxadiazole and benzene rings.

The structures of three 3-methyl-1H-1,2,4-triazole-5-thione derivatives are reported. The structure of 4-amino-3-methyl-1H-1,2,4-triazole-5(4H)-thione, C3H6N4S, (I), has been redetermined with an improved model for the H atoms: the non-H atoms of (I) all lie on mirror planes in space group Pbcm, and the H atoms of the methyl group are disordered over two sets of reflection-related atomic sites ...

In the title compound, C(17)H(18)N(2)O(4)S, where one of the N-4-methoxy-phenyl fragments is disordered over two sets of sites, the five-membered ring exhibits a nearly half-chair conformation and the two hydroxyl groups lie on opposite sides of the five-membered ring. In the crystal, the mol-ecules are linked into sheets parallel to (100) via O-H⋯O and O-H⋯S hydrogen bonds.

A series of 1-(2-hydroxyethyl)-3,5-dimethylpyrazolylazo derivatives, incorporating thiosemicarbazide 2a-c, 1,3,4-thiadiazole 3a-c, and 1,2,4-triazole-3-thione 4a-c were synthesized. The structure of these novel synthesized compounds 2a-c, 3a-c, and 4a-c was confirmed by spectral analysis. All these compounds were screened for their analgesic activity. Hot-plate and tail-immersion tests were use...