Study of the effectiveness use increasing doses mineral fertilizers (N 16 P K ...N 120 ) was carried out in 2020-2022 conditions Ryazan region on dark gray forest heavy loamy soil average fertility. The object research a new variety spring barley Raphael, included into State Register Russian Federation for Central (3) and Volga–Vyatka (4) Regions 2022 (patent No. 12254). As result research, the...

The endocytotic c-type lectin receptor DEC-205 is highly expressed on immature dendritic cells. In previous studies, it was shown that antigen-targeting to DEC-205 is a useful tool for the induction of antigen-specific Foxp3(+) regulatory T cells and thereby can prevent inflammatory processes. However, whether this approach is sufficient to mediate tolerance in mucosal tissues like the gut is u...

Through estimations of above-and below-ground standing biomass, annual biomass increment, fine root production and turnover, litterfall, canopy respiration and total soil CO 2 efflux, a carbon balance on seasonal and yearly timescales is developed for a Eucalypt open-forest savanna in northern Australia. This carbon balance is compared to estimates of carbon fluxes derived from eddy covariance ...

The role of the hematopoietic lineage-restricted minor histocompatibility (H) antigen HA-1 in renal allograft tolerance was explored. We obtained peripheral blood samples from three recipients of histocompatibility leukocyte antigen (HLA)-matched, HA-1-mismatched renal transplants, one of which had discontinued immunosuppression >30 yr ago while sustaining normal kidney function. Peripheral blo...

Shuttle vectors that replicate stably and express selectable phenotypes in both Thermococcus kodakaraensis and Escherichia coli have been constructed. Plasmid pTN1 from Thermococcus nautilis was ligated to the commercial vector pCR2.1-TOPO, and selectable markers were added so that T. kodakaraensis transformants could be selected by DeltatrpE complementation and/or mevinolin resistance. Based o...

To broaden the applicability of adoptive T-cell therapy for the treatment of hematologic malignancies, we aim to start a clinical trial using HA-1-TCR transferred virus-specific T cells. TCRs directed against the minor histocompatibility antigen (MiHA) HA-1 are good candidates for TCR gene transfer to treat hematologic malignancies because of the hematopoiesis-restricted expression and favorabl...

The study was carried out for two consecutive years (2005-06 to 2006-07) to evaluate the wheat response to five different levels (0, 4, 8, 12 and 16 kg ha) of manganese (Mn) alongwith 150-100-60 kg NPK ha application. The experiment was laid out in randomized complete block design (RCBD) with three repeats under irrigated conditions at Agriculture Research Farm Karor, District Layyah. NPK was a...

Although somatically mutated autoantibodies are characteristic of many autoimmune diseases, the processes that can lead to their development remain poorly understood. We have examined the formation of autoreactive memory B cells in PevHA mice, which express the influenza virus PR8 hemagglutinin (HA) as a transgenic membrane bound neo-self-Ag. Using a virus immunization strategy, we show that PR...

One approach to the fundamenta l problem of the mechanism of carcinogenesis by aromat ic hydrocarbons is t h rough the s tudy of the metabol ic products formed from the hydrocarbon. Weiger t and M:ottram (39, 40), af ter adminis t ra t ion of 3,4benzpyrene to rodents , dist inguished a series of metaboli tes a t different sites in the body, but only one, 8-hydroxybenzpyrene , was conclusively i...

Transgenic expression of the influenza virus hemagglutinin (HA) in the pancreatic islet beta cells of InsHA mice leads to peripheral tolerance of HA-specific T cells. To examine the onset of tolerance, InsHA mice were immunized with influenza virus A/PR/8 at different ages, and the presence of nontolerant T cells was determined by the induction of autoimmune diabetes. The data revealed a neonat...