P. BROWNBILL,1 D. MAHENDRAN,2 D. OWEN,3 P. SWANSON,4 K. L. THORNBURG,5 D. M. NELSON,6 AND C. P. SIBLEY1,7 Academic Unit of 1Child Health, 2Obstetrics and Gynaecology and 7School of Biological Sciences, 3Radioimmunoassay Laboratory, St. Mary’s Hospital, Manchester, M13 0JH United Kingdom; 5Department of Physiology, Oregon Health Sciences University, School of Medicine, Portland, Oregon 97201; an...

Spaanderman, M. E. A., M. Meertens, M. Van Bussel, T. H. A. Ekhart, and L. L. H. Peeters. Cardiac output increases independently of basal metabolic rate in early human pregnancy. Am J Physiol Heart Circ Physiol 278: H1585–H1588, 2000.—Early pregnancy is characterized by the institution of a high-flow low-resistance circulation. In this study, we tested the hypothesis that these hemodynamic chan...

Olsen, Henrik, Einar Vernersson, and Toste Länne. Cardiovascular response to acute hypovolemia in relation to age. Implications for orthostasis and hemorrhage. Am. J. Physiol. Heart Circ. Physiol. 278: H222–H232, 2000.— Venous compliance in the legs of aging man has been found to be reduced with decreased blood pooling (capacitance response) in dependent regions, and this might lead to misinter...

Jenni, Lukas, Susanne Jenni-Eiermann, Fernando Spina, and Hubert Schwabl. Regulation of protein breakdown and adrenocortical response to stress in birds during migratory flight. Am J Physiol Regulatory Integrative Comp Physiol 278: R1182–R1189, 2000.— During long-term fasting at rest, protein utilization is maintained at low levels until it increases at a threshold adiposity. This study examine...

JACQUES A. DURR,1,2 JOHANNES HENSEN,3 TOBIAS EHNIS,4 AND MARY S. BLANKENSHIP5 (With the Technical Assistance of C. Klein) 1Division of Nephrology, Department of Veterans Affairs Medical Center, Bay Pines 33744; 2Department of Medicine, University of South Florida College of Medicine, Tampa 33612; 3Klinikum Hannover Nordstadt, Medizinische Klinik, Hannover 30167; 4Department of Medicine IV, Univ...

FREDERICK E. ALBRECHT,1,2 JING XU,1 ORSON W. MOE,3 ULRICH HOPFER,4 WILLIAM F. SIMONDS,5 JOHN ORLOWSKI,6 AND PEDRO A. JOSE1,2 1Departments of Pediatrics, and 2Physiology and Biophysics, Georgetown University Medical Center, Washington, District of Columbia 20007; 3Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75235; 4Department of Physiology,...

BRIAN J. BLYTH,1 RICHARD L. HAUGER,2,3 ROBERT H. PURDY,2,3 AND JANET A. AMICO1,4,5 1Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh 15261; 4Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh 15261; 5Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15261; 2Department of Psychiatry, University of Ca...

Wang, L. D., M. Wang, A. Todisco, E. Grand, and J. Del Valle. The human histamine H2 receptor regulates c-jun and c-fos in a differential manner. Am J Physiol Cell Physiol 278: C1246–C1255, 2000.—Previously, we demonstrated that activation of the human H2 receptor (hH2R) leads to an increase in c-fos transcription and cell proliferation. The purpose of these studies was to examine whether hH2R ...

Wang, Yan, and Yoram Rudy. Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism. Am J Physiol Heart Circ Physiol 278: H1019–H1029, 2000.—Heterogeneity of myocardial structure and membrane excitability is accentuated by pathology and remodeling. In this study, a detailed model of the ventricular myocyte in a multicellular fiber was used t...

Kopp, Ulla C., Donna M. Farley, Michael Z. Cicha, and Lori A. Smith. Activation of renal mechanosensitive neurons involves bradykinin, protein kinase C, PGE2, and substance P. Am J Physiol Regulatory Integrative Comp Physiol 278: R937–R946, 2000.—Increased renal pelvic pressure or bradykinin increases afferent renal nerve activity (ARNA) via PGE2-induced release of substance P. Protein kinase C...