نتایج جستجو برای: 5 روش هیستوشیمیایی nadph دیافورزیز

تعداد نتایج: 1537394  

Journal: :The Journal of biological chemistry 2005
Loretha Carlisle-Moore Chris R Gordon Carl A Machutta W Todd Miller Peter J Tonge

The human fatty-acid synthase (HFAS) is a potential target for anti-tumor drug discovery. As a prelude to the design of compounds that target the enoyl reductase (ER) component of HFAS, the recognition of NADPH and exogenous substrates by the ER active site has been investigated. Previous studies demonstrate that modification of Lys-1699 by pyridoxal 5'-phosphate results in a specific decrease ...

Journal: :Agronomy 2022

Large crabgrass, Digitaria sanguinalis (L.) Scop., is a devastating weed species in the cotton (Gossypium spp.) fields China. It has developed resistance to haloxyfop-P-methyl, an aryloxyphenoxypropionate herbicide known for its ability inhibit lipid synthesis and induce oxidative stress weeds, due years of continuous intensive use. Here, we present results from nation-wide, long-term monitorin...

Journal: :American journal of physiology. Heart and circulatory physiology 2006
Hua Hong Jin-Sheng Zeng David L Kreulen David I Kaufman Alex F Chen

Statins have recently been shown to exert neuronal protection in ischemic stroke. Reactive oxygen species, specifically superoxide formed during the early phase of reperfusion, augment neuronal injury. NADPH oxidase is a key enzyme for superoxide production. The present study tested the hypothesis that atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived sup...

Journal: :Plant physiology 1981
M G Redinbaugh W H Campbell

The nitrate reductase activity of 5-day-old whole corn roots was isolated using phosphate buffer. The relatively stable nitrate reductase extract can be separated into three fractions using affinity chromatography on blue-Sepharose. The first fraction, eluted with NADPH, reduces nearly equal amounts of nitrate with either NADPH or NADH. A subsequent elution with NADH yields a nitrate reductase ...

Journal: :International journal of sport nutrition and exercise metabolism 2013
Jingmei Dong Peijie Chen Qing Liu Ru Wang Weihua Xiao Yajun Zhang

PURPOSE To examine the excessive reactive oxygen species (ROS) mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and the combined effect of glutamine supplementation and diphenyleneiodonium (DPI) on the function of neutrophils induced by overtraining. METHODS Fifty male Wistar rats were randomly divided into 5 groups: control group (C), overtraining group (E), DPI-admini...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2008
Niu Tian Rebecca S Moore William E Phillips Lin Lin Sharkeshia Braddy Janelle S Pryor Rachel L Stockstill Michael D Hughson R Davis Manning

The goal of this study was to test the hypothesis that NADPH oxidase contributes importantly to renal cortical oxidative stress and inflammation, as well as renal damage and dysfunction, and increases in arterial pressure. Fifty-four 7- to 8-wk-old Dahl salt-sensitive (S) or R/Rapp strain rats were maintained for 5 wk on a high sodium (8%) or high sodium + apocynin (1.5 mmol/l in drinking water...

Journal: :The Biochemical journal 1978
C H Reynolds P W Kuchel K Dalziel

1. The stoicheiometries and affinities of ligand binding to isocitrate dehydrogenase were studied at pH 7.0, mainly by measuring changes in NADPH and protein fluorescence. 2. The affinity of the enzyme for NADPH is about 100-fold greater than it is for NADP+ in various buffer/salt solutions, and the affinities for both coenzymes are decreased by Mg2+, phosphate and increase in ionic strength. 3...

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