Cutaneous adverse reactions to benzodiazepines seem to be rare. We report a 61-year-old man with adverse reactions after ingestion of metamizole, diclofenac, and tetrazepam. Skin prick tests with metamizole, diclofenac, and tetrazepam were negative. Patch tests with metamizole, diclofenac, and tetrazepam (all at 5% in aqueous solution) were performed, and were positive for tetrazepam. Oral chal...

Buspirone (Buspar; Bristol) marks a departure from established concepts of anxiolysis. Differing substantially both in its mode of action and in the clinical expression of its action from agents such as barbiturates and benzodiazepines, it would seem to operate chiefly via the 5-HT1A subtype of serotonin receptor. Such receptor selectivity is likely to be responsible for the novel action of thi...

Purpose: Illicit drug use poses a great threat to the integrity of our society and can lead major problems such as traffic workplace accidents, homicides, theft, terrorism mongering suicide name few. Among variety commonly used drugs-of-abuse, cannabis, cocaine, opiates, amphetamine its derivatives have been most reported. Oral fluid testing has gaining interest an accurate screening method for...

The undue use of benzodiazepines particularly among women has raised concern in the public health area. This qualitative study aimed at understanding the beliefs and values associated with undue use of benzodiazepines among women. Thirty-three participants (aged between 18 and 60) with a history of undue use of benzodiazepines in the past year were selected intentionally using specific criteria...

BACKGROUND The aim of this study was to explore the association between age and care of patients with depression in primary care setting. A comparison was made among the groups of elderly patients, middle aged patients and younger patients with diagnosis of depressive episode (F32). SUBJECTS AND METHODS Patients (17.290) from ten GP offices in the city of Zagreb formed the representative samp...

1,5-benzodiazepines are regarded as one of the most important classes of heterocyclic compounds as privileged structures and have vast range of applications in the field of medicine and chemistry. They are therefore attractive synthetic targets for organic and medicinal chemist. The current review article mainly covers the multicomponent green chemistry approaches for the synthesis of 1,5-benzo...