Background: Gastroschisis is a congenital malformation characterized by the extrusion of the fetal bowel during intrauterine life, secondary to a defect in anterior abdominal wall. Objective: To establish an experimental model of gastroschisis in fetuses of rats exposed to acetylsalicylic acid (ASA), during pregnancy. Methods: Wistar rats were treated with an oral single ASA dose of 50, 500, 75...

Ethylene glycol (CAS RN 107-21-1) can cause kidney toxicity via the formation of calcium oxalate crystals in a variety of species, including humans. Numerous repeated dose studies conducted in rats have indicated that male rats are more susceptible than female rats. Furthermore, subchronic and chronic studies using different dietary exposure regimens have indicated that male Wistar rats may be ...

The research was carried out to evaluate the in-vitro antimicrobial activity and phytochemical constituents of Cassia occ dential s. Cassia leaves were collected from Kacha town in Niger State and extracted using methano , hexane, chloroform and water extraction methods. Serial concentrations: 50 60, 70, 80, 90 and 100 % methanol, hexane, chloroform and aqueous extracts were prepared and steril...

Anethum graveolens L. (dill) is used widely in Asian food and folk medicine but its safety profile for further clinical studies has remained unclear. After administration of total hydroalcoholic extract to mice in acute, subacute and subchronic treatment periods, toxic responses were recoreded by clinical, biochemical, hematological and pathological examinations. Doses up to 2000 mg/kg in acute...

Methods The ethyl acetate extract of Pedalium murex L., (250, 500, and 1000 mg/kg body weight) was administered orally to three groups of rats (five animals per group) in order to evaluate the activity of the extract against castor oil-induced diarrhea model in rat. Two other groups received normal saline (5mg/kg) and loperamide (5mg/kg) as positive control. The effect of the extract on intesti...

the purposes of this research were to the evaluation of resistance to nickel and cadmium in 52 indigenous and non-indigenous strains of contaminated soils and a study of growth promoting characteristics of some resistant isolates. resistance test at three levels of cadmium (0, 100, 200 mg l-1) and five levels of nickel (0, 250, 500, 750, 1000 mg l-1) in the framework of a completely randomized ...

The effectiveness of glycine in treating experimental lead intoxication was examined in rats. Male Wistar rats were exposed to 3 g/L lead acetate in drinking water for 5 weeks and treated thereafter with glycine (100 and 500 mg/kg, orally) once daily for 5 days or glycine (1000 mg/kg, orally) once daily for 28 days. The effect of these treatments on parameters indicative of oxidative stress (gl...

OBJECTIVES Ofatumumab is a human IgG1κ monoclonal antibody that targets a membrane proximal epitope encompassing the small and large loops of CD20. This Phase I study evaluated the safety, tolerability, efficacy and pharmacokinetics of ofatumumab monotherapy in Japanese patients with relapsed/refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma. METHODS Ofatumumab was...

Available sample data of 270 water samples collected from different intake sources of Nepal is analyzed. Analysis showed that well waters were the hardest with more than 60% samples recording hardness above 180 mg/l whereas stream and spring waters showed only 20% and 10% in the same range, respectively. Total dissolved solid (TDS) contents in spring and stream waters were below 500 mg/l while ...

afforestation of contaminated areas is considered as a possible strategy for reduction of contaminations. in the present study, the effects of lead (pb) and cadmium (cd) were investigated on chlorophyll fluorescence parameters (fv/fm, fo, and fm), photosynthetic pigments (chlorophyll a, b, and total chlorophyll), and proline in one-year-old seedlings of celtis caucasica and robinia pseudoacacia...