Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, and generally considered to be caused by environment and genetic factors. In this study, we combined a genome-wide haplotype association study (GWHAS) and gene prioritization strategy to mine AML-related genetic affect factors and understand its pathogenesis. A total of 175 AML patients were downloaded from the public ...

PCA3 (prostate cancer gene 3) and multiparametric 3 tesla MRI are new promising diagnostic tools in the detection of PCa. Our aim was to study the clinical value of the Progensa PCA3-test: its predictive value for biopsy outcome, Gleason score and MRI outcome. We evaluated, retrospectively, 591 patients who underwent a Progensa PCA3-test at the Radboud University Nijmegen Medical Centre between...

Recently we investigated in [SIAM J. Optim., 19 (2008), pp. 572–591] hierarchies of semidefinite approximations for the chromatic number χ(G) of a graph G. In particular, we introduced two hierarchies of lower bounds: the “ψ”-hierarchy converging to the fractional chromatic number and the “Ψ”-hierarchy converging to the chromatic number of a graph. In both hierarchies the first order bounds are...

Involvement of protein kinase ζ in the maintenance of hippocampal long-term 1 potentiation in rats with chronic visceral hypersensitivity 2 Authors 3 Aiqin Chen*, Chengjia Bao*, Ying Tang, Xiaoqing Luo, Lixia Guo, Bin Liu, 4 Chun Lin 5 * These two authors contributed equally to this work; § Corresponding author. 6 7 Affiliation 8 Fujian Medical University, School of Basic Medical Sciences, Labo...

Acquired mutations in the FLT3 receptor tyrosine kinase are common in acute myeloid leukemia and result in constitutive activation. The most frequent mechanism of activation is disruption of the juxtamembrane autoregulatory domain by internal tandem duplications (ITDs). FLT3-ITDs confer factor-independent growth to hematopoietic cells and induce a myeloproliferative syndrome in murine bone marr...