In Alcaligenes eutrophus CH34, determinants encoding inducible resistance to chromate (chr) and to cobalt and nickel (cnr) are located adjacent to each other on plasmid pMOL28. To develop metal-sensing bacterial strains, a cloned part of plasmid pMOL28, which contains both determinants, was mutated with Tn5-lacZ. The chr::lacZ fusions were specifically induced by chromium; cnr was induced best ...

The effects of thiol compounds (L-cysteine ethyl ester, 2,3-dimercaptosuccinic acid, or 2,3-dimercapto-1-propanesulfonic acid) on the toxicity induced by chromate (potassium dichromate) were investigated in HeLa cells and mice. Chromate-induced cytotoxicity evaluated by inhibition of cell growth and chromium content of the cells was diminished by all of the thiol compounds tested when the cells...

A coordination cage with an elusive icosahedral geometry was obtained by K+-induced rearrangement of a hexanuclear [(cymene)Ru(pyridine-3,5-dicarboxylate)]6 complex.

Chromate is an established human carcinogen. There have been many studies of the reactivity of chromate aimed at improving understanding of chromate toxicity. In the present paper a number of conclusions of these studies are reviewed and considered in the light of new results obtained in our laboratories. A number of hypotheses are considered; it is concluded, however, that it is impossible to ...

Particulate hexavalent chromium ((Cr(VI)) compounds are human lung carcinogens. These compounds induce DNA damage, chromosome aberrations, and concentration-dependent cell death in human and Chinese hamster ovary (CHO) cells. The relationship between Cr(VI)-induced DNA damage and chromosome aberrations is poorly understood. Accordingly, this study focused on examining the role of Ku80, a gene i...

WATANABE, M., TAKAYAMA, Y., KOIKE, M. and YAMAMOTO, M. In Vivo Clastogenicity of Lead Chromate in Mice. Tohoku J. exp. Med., 1985, 146 (3), 373-374 Cytogenetical effects of lead chromate were evaluated in vivo. When 0.5, 1, 2 and 4 g/kg body weight of lead chromate suspensions in 0.5% gum arabic were administered i.p. to C57BL/6N male mice twice, the frequencies of micronucleated polychromatic ...

Reactions of rare earth chlorides, N-(phosphonomethyl)iminodiacetic acid (H(4)pmida) and ferrous oxalate dihydrate under ionothermal conditions result in four new isostructural 3d-4f heterometal coordination polymers, [LnFe(III)Fe(6)(Hpmida)(6)]·2H(2)O {Ln = Eu (1), Dy (2), Ho (3) and Y (4)}. All compounds were characterized by infrared spectroscopy, elemental analysis, thermogravimetric analys...

The geno- and cytotoxicity of chromate, an important environmental pollutant, is partly attributed to the flavoenzyme-catalyzed reduction with the concomitant formation of reactive oxygen species. The aim of this work was to characterize the role of NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase, EC 1.6.99.2) and glutathione reductase (GR, EC 1.6.4.2) in the mammalian cell cytotoxicity of ...

The title compound, octaaqua-(hydrogendifluorido)-di-cop-per(II) hexa-fluoridoaluminate dihydrate, was obtained under hydro-thermal conditions. The structure is isotypic with that of the analogous Fe(III) compound, [Cu(2)(HF(2))(H(2)O)(8)][FeF(6)]·2H(2)O. The coordination sphere of the Cu(II) atom is formed by one F and three water O atoms at short distances < 2 Å and is augmented by two additi...

Hexavalent chromium (Cr(VI)) is a serious environmental pollutant and human toxicant. Mammalian cells are very sensitive to chromate as they lack efficient chromate detoxifying strategy, e.g., chromate-reducing genes that are widely present in prokaryotes. To test whether introduction of prokaryotic chromate-reducing gene into mammalian cells could render higher chromate resistance, an Escheric...