Glutathione S-transferases (GSTs) constitute an important class of phase II (de)toxifying enzymes, catalysing the conjugation of glutathione (GSH) with electrophilic compounds. In the present study, Km, kcat and kcat/Km values for the rat GST 1-1-, 3-3-, 4-4- and 7-7-catalysed conjugation reactions between GSH and a series of 10 different 2-substituted 1-chloro-4-nitrobenzenes, and the second-o...

Three novel new compounds derived from antiparasitic precursors have been synthesized and tested for their antiamoebic and antigiardial activities. The condensation of 2-(2-methyl-5-1H-nitroimidazolyl)ethylamine (6) with 5-nitro-2-furylacrylic acid (7) gave 3-(5-nitrofuran-2-yl)-N-[2-(5-nitroimidazol-1-yl)ethyl]acrylamide (8). Condensation of 7 with 7-chloro-4-(piperazin-1-yl)quinoline (9) affo...

CD spectra of a series of 5-aryl-7-chloro-l,3,4,5-tetrahydro2H-l,4-benzodiazepin-2-one derivatives having different substituents at positions 1, 3, 4, and 5 were studied. The absolute eonfiguration at C-5 of two homochiral analogues, 1 and 2, having enantiomorphous ring conformations was determined on the basis of chiroptical correlations and theoretical calculations. The latter have shown that...

Molecular docking is an important tool in drug research. Thanks to these calculations, the type and magnitude of interactions molecules with target are evaluated. It also possible perform more detailed analyzes than known experimental methods easy economical way by using results obtained current scientific developments examine different depending on bioactivity type. Cancer researches show that...