A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1 1 C.A. Lasagna-Reeves, M.W.C. Rousseaux, M.J. Guerrero-Munoz, J. Park, 2 P. Jafar-Nejad,R. Richman, N. Lu, U.Sengupta, A. Litvinchuk, 3 H.T. Orr, R. Kayed and H.Y. Zoghbi * 4 5 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 6 2 Jan and Dan Duncan Neurological Research Insti...

A major productivity hurdle for parallel programming is the presence of data races. Data races can lead to all kinds of harmful program behaviors, including determinism violations and corrupted memory. However, runtime overheads of current dynamic data race detectors are still prohibitively large (often incurring slowdowns of 10× or more) for use in mainstream software development. In this pape...

background: the incidence of colorectal cancer is rising in several developing countries. in the absence of integrated endoscopy and pathology databases, adenoma detection rate (adr), as a validated quality indicator of screening colonoscopy, is generally difficult to obtain in practice. we aimed to measure the correlation of polyp-related indicators with adr in order to identify the most accur...

(Fam Med 2003;35(5):314-5.) Editor’s Note: In this month’s column, John P. Langlois, MD, of the Mountain Area Health Education Center in Asheville, NC, reviews the history of precepting in medical education and describes the important role that 21st century preceptors will have in teaching students about current and future health care trends. I welcome your comments about this feature, which is...

1 Department of Mathematics, Donga-A University, Pusan 604-714, South Korea 2 Division of General Edu.-Math., Kwangwoon University, Seoul 139-701, South Korea 3 Department of Mathematics and Computer Science, Konkook University, Chungju 139-701, South Korea 4 Department of Mathematics, Kyungpook National University, Taegu 702-701, South Korea 5 Department of Computer Science, Chungbuk National ...

Pleiotrophin (PTN) was found to regulate tyrosine phosphorylation of beta-adducin through the PTN/receptor protein tyrosine phosphatase (RPTP)beta/zeta signaling pathway. We now demonstrate that PTN stimulates the phosphorylation of serines 713 and 726 in the myristoylated alanine-rich protein kinase (PK) C substrate domain of beta-adducin through activation of either PKC alpha or beta. We also...