Decanoic acid is used as an additive in injections to prolong the action of drugs because its lipid solubility. In addition, decanoic has been speculated have anti-inflammatory effects. this study, we examined effects on a mouse model dinitrofluorobenzene (DNFB)-induced irritant contact dermatitis. Mice were divided into four treatment groups. Groups 1, mice challenged with twice application 50...

Large-scale ecotoxicological studies have technical and ethical limitations, both related to the need expose individuals potentially harmful compounds. Computational modeling is a complementary useful predictive tool that overcomes these limitations. Considering increasing interest in effects of pesticides on behavioral traits, aim this study was evaluate chlorpyrifos (CPF) intra- inter-specifi...

This study investigated the degradation characteristics of propylbenzenes (PBZs, including isopropylbenzene and n-propylbenzene), with high leakage risks ecological hazards, by a newly isolated marine microalga named Rhinomonas reticulata S6A which is promising candidate for eco-friendly bioremediation from marine. About 72% 56% n-PBZ i-PBZ can be degraded after 7 days in culture. The acute tox...

in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decrea...

dimethoate (organophosphate insecticide) and lambda-cyhalothrin (synthetic pyrithroid) aretwo frequently used pesticides due to their high effectiveness and rapid breakdown into environmentally safeproducts. the aim of this present study was to assess and compare the acute toxicity of dimethoate(rogor30%ec) and lambda-cyhalothrin (5%ec) on labeo rohita (hamilton). acute toxicity bioassay wascar...

in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decreas...

The presence of p53-pathway dysfunction in chronic lymphocytic leukemia (CLL) can be used to identify patients with chemotherapy-refractory disease. Therapeutic responses are known to vary between patients with chemosensitive CLL and may relate to differences in p53-pathway activity. We hypothesized that the magnitude or type of p53-pathway protein expression is heterogeneous in patients with c...

This study comprehensively investigated the influences of salinity, exposure concentration and time on the aggregate size, surface charge and dissolution of zinc oxide nanoparticles (ZnO-NPs; 20nm) in seawater, and examined the interacting effect of salinity and waterborne exposure of ZnO-NPs on the marine diatom Thalassiosira pseudonana for 96h. We found that aggregate sizes of ZnO-NPs signifi...

Retinoblastoma, a very aggressive cancer of the developing retina, initiatiates by the biallelic loss of RB1 gene, and progresses very quickly following RB1 inactivation. While its genome is stable, multiple pathways are deregulated, also epigenetically. After reviewing the main findings in relation with recently validated markers, we propose an integrative bioinformatics approach to include in...