Copy number variations (CNVs) are associated with many complex diseases. Next generation sequencing data enable one to identify precise CNV breakpoints to better under the underlying molecular mechanisms and to design more efficient assays. Using the CIGAR strings of the reads, we develop a method that can identify the exact CNV breakpoints, and in cases when the breakpoints are in a repeated r...

To the Editor-in-Chief: We respectfully resubmit to BMC Public Health our manuscript (#1872779892138581) entitled " Systematic review of cigar smoking and all-cause and smoking-related mortality. " We have revised the manuscript based on the comments from the reviewers. Please see below, the point-by-point response to each of the reviewer comments, including the revisions made to the manuscript...

Cigarette smoking is an important and well-established cause of pancreatic cancer. In contrast, little is known about the effects of smoking cigars, pipes, and use of smokeless tobacco on pancreatic cancer risk. The objective of the present study was to examine the association between noncigarette tobacco use (i.e., cigars, pipes, smokeless tobacco) and pancreatic cancer risk among nonsmokers o...